Osong Public Health and Research Perspectives

Jongyul Roh

1 Article

Autochthonous Lyme Borreliosis in Humans and Ticks in Korea: Shinje Moon, Jin Gwack, Kyu Jam Hwang, Donghyuk Kwon, Suyeon Kim, Yoontae Noh, Jongyul Roh, E-hyun Shin, Kyungjin Jeong, Wonseok Seok, Seung-Ki Youn; Osong Public Health Res Perspect. 2013;4(1):52-56. Published online February 28, 2013; DOI: https://doi.org/10.1016/j.phrp.2012.12.001

2,789 View
15 Download
17 Citations

Objective: This study aimed at finding epidemiological and clinical features of autochthonous Lyme borreliosis in humans through epidemiological investigations and identifying its vectors and pathogens through analysis of ticks.
Method
Epidemiological investigations, including review of the retrospective medical records and patient interviews, were conducted in two cases that occurred in 2012. To identify the vectors and pathogens, ticks were collected between September 23 and October 6, 2012 from the area where the tick bite in the first patient occurred. The ticks were classified, and polymerase chain reaction (PCR) tests and cultures were performed.
Results
The first patient, a 46-year-old female, visited a forest in Gangwon province, which was 900 m above sea level, where the tick bite occurred. Two weeks after the tick bite, erythema migrans (12 × 6 cm² in size) appeared on the site of tick bite, along with fever, chill, fatigue, myalgia, and arthralgia on shoulders, knees, and hips. The second patient, a 44-year-old male, visited a mountain in Gangwon province, which was 1200 m above sea level, where a tick bite occurred. One month after the tick bite, erythema migrans appeared at the site of the tick bite, along with fatigue, myalgia, and arthralgia on the right shoulder and temporomandibular joint. Indirect fluorescent antibody testing and Western blotting were carried out in these two cases for diagnosis, and positive findings were obtained. As a result, Lyme borreliosis could be confirmed. To estimate the pathogens and vectors, the ticks were collected. A total of 122 ticks were collected and only two species, Haemaphysalis japonica and Haemaphysalis flava, were identified. PCR and culture were performed on ticks. However, Borrelia burgdo rferi sensu lato was not isolated from any collected ticks.
Conclusions
This study is significant to confirm Lyme borreliosis officially at first by the national surveillance system, although identification of the mites and pathogens failed.

Citations

Citations to this article as recorded by

ОЦІНЮВАННЯ ПОВНОТИ РЕЄСТРАЦІЇ КЛІЩОВИХ ІНФЕКЦІЙ НА ТЕРНОПІЛЛІ
В. О. Паничев, М. А. Андрейчин, А. С. Сверстюк
Інфекційні хвороби.2023; (1): 18. CrossRef
Surveillance and Molecular Identification ofBorreliaSpecies in Ticks Collected at U.S. Army Garrison Humphreys, Republic of Korea, 2018–2019
Seung-Ho Lee, Sung-Tae Chong, Heung-Chul Kim, Terry A Klein, Kyungmin Park, Jingyeong Lee, Jeong-Ah Kim, Won-Keun Kim, Jin-Won Song, Sarah Hamer
Journal of Medical Entomology.2022; 59(1): 363. CrossRef
De novo transcriptome sequencing and comparative profiling of the ovary in partially engorged and fully engorged Haemaphysalis flava ticks
Yu Zhao, Zhe-Hui Qu, Feng-Chao Jiao
Parasitology International.2021; 83: 102344. CrossRef
Characterization of AV422 from Haemaphysalis flava ticks in vitro
Lei Liu, Hao Tang, De-yong Duan, Jin-bao Liu, Jie Wang, Li-li Feng, Tian-yin Cheng
Experimental and Applied Acarology.2021; 84(4): 809. CrossRef
iSeq 100 for metagenomic pathogen screening in ticks
Ju Yeong Kim, Myung-hee Yi, Alghurabi Areej Sabri Mahdi, Tai-Soon Yong
Parasites & Vectors.2021;[Epub] CrossRef
Study on the Epidemiological Features of Lyme Disease in Korea between 2011 and 2018
Choong Won Seo
The Korean Journal of Clinical Laboratory Science.2019; 51(4): 436. CrossRef
Cathepsin L—a novel cysteine protease from Haemaphysalis flava Neumann, 1897
Yali Sun, Lan He, Long Yu, Jiaying Guo, Zheng Nie, Qin Liu, Junlong Zhao
Parasitology Research.2019; 118(5): 1581. CrossRef
Tick saliva microbiomes isolated from engorged and partially fed adults of Haemaphysalis flava tick females
X.‐M. He, T.‐Y. Cheng
Journal of Applied Entomology.2018; 142(1-2): 173. CrossRef
Molecular detection of Rickettsia species in ticks collected from the southwestern provinces of the Republic of Korea
Yoontae Noh, Yeong Seon Lee, Heung-Chul Kim, Sung-Tae Chong, Terry A. Klein, Ju Jiang, Allen L. Richards, Hae Kyeong Lee, Su Yeon Kim
Parasites & Vectors.2017;[Epub] CrossRef
Borrelia Species Detected in Ticks Feeding on Wild Korean Water Deer (Hydropotes inermis) Using Molecular and Genotypic Analyses
D. VanBik, S. H. Lee, M. G. Seo, B. R. Jeon, Y. K. Goo, S. J. Park, M. H. Rhee, O. D. Kwon, T. H. Kim, P.J.L. Geraldino, D. Kwak
Journal of Medical Entomology.2017; 54(5): 1397. CrossRef
Serological Detection of Borrelia burgdorferi among Horses in Korea
Seung-Hun Lee, Sun-Hee Yun, Eunsang Choi, Yong-Soo Park, Sang-Eun Lee, Gil-Jae Cho, Oh-Deog Kwon, Dongmi Kwak
The Korean Journal of Parasitology.2016; 54(1): 97. CrossRef
De novo assembly and analysis of midgut transcriptome of Haemaphysalis flava and identification of genes involved in blood digestion, feeding and defending from pathogens
Xing-Li Xu, Tian-Yin Cheng, Hu Yang, Zhi-Hui Liao
Infection, Genetics and Evolution.2016; 38: 62. CrossRef
Enolase, a plasminogen receptor isolated from salivary gland transcriptome of the ixodid tick Haemaphysalis flava
Xing-Li Xu, Tian-Yin Cheng, Hu Yang
Parasitology Research.2016; 115(5): 1955. CrossRef
Seasonal Patterns of Ticks in Pocheon and Cheolwon, Republic of Korea
Yong Chil Shin, In Yong Lee, Jang Hoon Seo
Korean Journal of Clinical Laboratory Science.2015; 47(3): 147. CrossRef
Epidemiological Features and Clinical Manifestations of Lyme Borreliosis in Korea during the Period 2005^|^ndash;2012
Shinje Moon, Yeongseon Hong, Kyu-Jam Hwang, Suyeon Kim, Jihye Eom, Donghyok Kwon, Ji-Hyuk Park, Seung-Ki Youn, Aeree Sohn
Japanese Journal of Infectious Diseases.2015; 68(1): 1. CrossRef
Insight into the Pathogenesis of Lyme Disease
Ok Sarah Shin
Journal of Bacteriology and Virology.2014; 44(1): 10. CrossRef
Epidemic Intelligence Service Officers and Field Epidemiology Training Program in Korea
Geun-Yong Kwon, Shinje Moon, Wooseok Kwak, Jin Gwack, Chaeshin Chu, Seung-Ki Youn
Osong Public Health and Research Perspectives.2013; 4(4): 215. CrossRef

Author index