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Jong Ho Lee 1 Article
Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys
Young Sim Choi, Han Byul Jang, Ju Yeon Park, Hye-Ja Lee, Jae-Heon Kang, Kyung-Hee Park, Jong Ho Lee, Sang Ick Park, Jihyun Song
Osong Public Health Res Perspect. 2014;5(5):251-257.   Published online October 31, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.08.008
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  • 8 Citations
AbstractAbstract PDF
Objectives
Obesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid (PL) features and metabolic parameters in young individuals may strengthen the utility of fatty acid composition as an early biomarker of future metabolic disorders.
Methods
Anthropometric and blood biochemical data were obtained from 131 Korean males aged 10.5 ± 0.4 years, and followed up at 2 years. We analyzed the plasma PL fatty acids according to obesity. Obese children were defined as those with a body mass index (BMI) greater than the 85th percentile for age and gender, based on Korean child growth standards.
Results
Activities of lipid desaturases, stearyl-CoAD (SCD-16,16:1n-7/16:0), delta-6D (D6D, 20:3n-6/18:2n-6), and delta-5D (D5D, 20:4n-6/20:3n-6), were estimated. Obese individuals had significantly higher proportions of palmitoleic acid (16:1n-7) and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at both baseline and follow-up than did lean individuals. The activities of SCD-16 and D6D were higher in obese than lean boys. The baseline SCD-16 activity level was positively associated with the baseline waist circumference (WC) and the metabolic risk score. The baseline D6D level was positively associated with WC and also with the homeostasis model of assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (IR), and metabolic risk score at both baseline and follow-up.
Conclusion
In young Korean males, higher D6D activity predicts the future development of IR and associated metabolic disorders including dyslipidemia.

Citations

Citations to this article as recorded by  
  • Palmitoleic and Dihomo-γ-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children
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    Frontiers in Pediatrics.2021;[Epub]     CrossRef
  • Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?
    Camila O. de Souza, Gretchen K. Vannice, José C. Rosa Neto, Philip C. Calder
    Molecular Nutrition & Food Research.2018; 62(1): 1700504.     CrossRef
  • Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children
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    Journal of the American College of Nutrition.2018; 37(1): 44.     CrossRef
  • Continuous cardiometabolic risk score definitions in early childhood: a scoping review
    M. Kamel, B. T. Smith, G. Wahi, S. Carsley, C. S. Birken, L. N. Anderson
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    Scientific Reports.2016;[Epub]     CrossRef
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    A. Viitasalo, J. Ågren, T. Venäläinen, J. Pihlajamäki, J. Jääskeläinen, A. Korkmaz, M. Atalay, T. A. Lakka
    Pediatric Obesity.2016; 11(4): 299.     CrossRef
  • Linoleic acid and the pathogenesis of obesity
    Shaan S. Naughton, Michael L. Mathai, Deanne H. Hryciw, Andrew J. McAinch
    Prostaglandins & Other Lipid Mediators.2016; 125: 90.     CrossRef
  • Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats
    Venkatesh Gopalan, Navin Michael, Seigo Ishino, Swee Shean Lee, Adonsia Yating Yang, K. N. Bhanu Prakash, Jadegoud Yaligar, Suresh Anand Sadananthan, Manami Kaneko, Zhihong Zhou, Yoshinori Satomi, Megumi Hirayama, Hidenori Kamiguchi, Bin Zhu, Takashi Hori
    Scientific Reports.2016;[Epub]     CrossRef

PHRP : Osong Public Health and Research Perspectives