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Jae-Sug Lee 2 Articles
Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation
Jae-Sug Lee, Seong-Ryeol Kim, Jae-Hyoung Song, Yong-Pyo Lee, Hyun-Jeong Ko
Osong Public Health Res Perspect. 2018;9(6):334-339.   Published online December 31, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.6.07
  • 3,245 View
  • 60 Download
  • 4 Citations
AbstractAbstract PDF
Objectives

Human rhinoviruses (HRVs) are the major cause of the common cold. Currently there is no registered, clinically effective, antiviral chemotherapeutic agent to treat diseases caused by HRVs. In this study, the antiviral activity of dexamethasone (DEX) against HRV1B was examined.

Methods

The anti–HRV1B activity of DEX was assessed by sulforhodamine B assay in HeLa cells, and by RT-PCR in the lungs of HRV1B-infected mice. Histological evaluation of HRV1B-infected lungs was performed and a histological score was given. Anti-HRV1B activity of DEX via the glucocorticoid receptor (GCR)-dependent autophagy activation was assessed by blocking with chloroquine diphosphate salt or bafilomycin A1 treatment.

Results

In HRV1B-infected HeLa cells, treatment with DEX in a dose-dependent manner, resulted in a cell viability of > 70% indicating that HRV1B viral replication was reduced by DEX treatment. HRV1B infected mice treated with DEX, had evidence of reduced inflammation and a moderate histological score. DEX treatment showed antiviral activity against HRV1B via GCR-dependent autophagy activation.

Conclusion

This study demonstrated that DEX treatment showed anti-HRV1B activity via GCR-dependent autophagy activation in HeLa cells and HRV1B infected mice. Further investigation assessing the development of topical formulations may enable the development of improved DEX effectiveness.

Citations

Citations to this article as recorded by  
  • Intracellular translocation of HMGB1 is important for Zika virus replication in Huh7 cells
    Kim-Ling Chin, Nurhafiza Zainal, Sing-Sin Sam, Pouya Hassandarvish, Rafidah Lani, Sazaly AbuBakar
    Scientific Reports.2022;[Epub]     CrossRef
  • Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19
    Gustavo José da Silva Pereira, Anderson Henrique França Figueredo Leão, Adolfo Garcia Erustes, Ingrid Beatriz de Melo Morais, Talita Aparecida de Moraes Vrechi, Lucas dos Santos Zamarioli, Cássia Arruda Souza Pereira, Laís de Oliveira Marchioro, Letícia P
    International Journal of Molecular Sciences.2021; 22(8): 4067.     CrossRef
  • MSTN Attenuates Cardiac Hypertrophy through Inhibition of Excessive Cardiac Autophagy by Blocking AMPK /mTOR and miR-128/PPARγ/NF-κB
    Hanping Qi, Jing Ren, Lina Ba, Chao Song, Qianhui Zhang, Yonggang Cao, Pilong Shi, Bowen Fu, Yongsheng Liu, Hongli Sun
    Molecular Therapy - Nucleic Acids.2020; 19: 507.     CrossRef
  • Autophagy Augmentation to Alleviate Immune Response Dysfunction, and Resolve Respiratory and COVID-19 Exacerbations
    Garrett Pehote, Neeraj Vij
    Cells.2020; 9(9): 1952.     CrossRef
Antiviral Activity of Itraconazole against Echovirus 30 Infection In Vitro
Jae-Sug Lee, Hwa-Jung Choi, Jae-Hyoung Song, Hyun-Jeong Ko, Kyungah Yoon, Jeong-Min Seong
Osong Public Health Res Perspect. 2017;8(5):318-324.   Published online October 31, 2017
DOI: https://doi.org/10.24171/j.phrp.2017.8.5.05
  • 3,094 View
  • 23 Download
  • 6 Citations
AbstractAbstract PDF
Objectives

Echovirus 30 is a major cause of meningitis in children and adults. The aim of this study was to investigate whether the antifungal drug itraconazole could exhibit antiviral activity against echovirus 30.

Methods

The cytopathic effect and viral RNA levels were assessed in RD cells as indicators of viral replication. The effects of itraconazole were compared to those of two known antiviral drugs, rupintrivir and pleconaril. The time course and time-of-addition assays were used to approximate the time at which itraconazole exerts its activity in the viral cycle.

Results

Itraconazole and rupintrivir demonstrated the greatest potency against echovirus 30, demonstrating concentration-dependent activity, whereas pleconaril showed no antiviral activity. Itraconazole did not directly inactivate echovirus 30 particles or impede viral uptake into RD cells, but did affect the initial stages of echovirus 30 infection through interference with viral replication.

Conclusion

Itraconazole can be considered a lead candidate for the development of antiviral drugs against echovirus 30 that may be used during the early stages of echovirus 30 replication.

Citations

Citations to this article as recorded by  
  • Antiviral Activity of Approved Antibacterial, Antifungal, Antiprotozoal and Anthelmintic Drugs: Chances for Drug Repurposing for Antiviral Drug Discovery
    Leena Abdulaziz, Esraa Elhadi, Ejlal A Abdallah, Fadlalbaseer A Alnoor, Bashir A Yousef
    Journal of Experimental Pharmacology.2022; Volume 14: 97.     CrossRef
  • Identification of novel Ebola virus inhibitors using biologically contained virus
    Bert Vanmechelen, Joren Stroobants, Winston Chiu, Joost Schepers, Arnaud Marchand, Patrick Chaltin, Kurt Vermeire, Piet Maes
    Antiviral Research.2022; 200: 105294.     CrossRef
  • The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication
    Lucca R. Policastro, Isabela Dolci, Andre S. Godoy, José V. J. Silva Júnior, Uriel E. A. Ruiz, Igor A. Santos, Ana C. G. Jardim, Kirandeep Samby, Jeremy N. Burrows, Timothy N. C. Wells, Laura H. V. G. Gil, Glaucius Oliva, Rafaela S. Fernandes
    Viruses.2022; 14(7): 1351.     CrossRef
  • Antifungal Triazole Posaconazole Targets an Early Stage of the Parechovirus A3 Life Cycle
    Eric Rhoden, Terry Fei Fan Ng, Ray Campagnoli, W. Allan Nix, Jennifer Konopka-Anstadt, Rangaraj Selvarangan, Laurence Briesach, M. Steven Oberste, William C. Weldon
    Antimicrobial Agents and Chemotherapy.2020;[Epub]     CrossRef
  • Potential antiviral properties of antifungal drugs
    FalahH.O Al-Khikani, HudaA.S Almosawey, YounusJ Abdullah, AtyafA Al-Asadi, RaghdahM Hameed, NoorF Hasan, MohanadK.M Al-Ibraheemi
    Journal of the Egyptian Women's Dermatologic Socie.2020; 17(3): 185.     CrossRef
  • Repurposing approach identifies new treatment options for invasive fungal disease
    Isis Regina Grenier Capoci, Daniella Renata Faria, Karina Mayumi Sakita, Franciele Abigail Vilugron Rodrigues-Vendramini, Patricia de Souza Bonfim-Mendonça, Tania Cristina Alexandrino Becker, Érika Seki Kioshima, Terezinha Inez Estivalet Svidzinski, Berna
    Bioorganic Chemistry.2019; 84: 87.     CrossRef

PHRP : Osong Public Health and Research Perspectives