- Original Article
- How Should Biobanks Collect Biosamples for Clinical Application? A 20-year Biomarker-related Publication and Patent Trend Analysis
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Jae-Eun Lee
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Osong Public Health Res Perspect. 2018;9(3):105-111. Published online June 30, 2018
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Objectives
This study was designed to analyze biomarker-related publications and patent trends which biobanks could consider in planning biosample collections for biomarker research.
Methods
Publications and patents containing the term “biomarker” in the title published between 1998 to 2017 were retrieved using Scopus database and Google Patents search engine.
Results
Over the last 20 years there has been a steady increase in biomarker-related publications and... |
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- Original Article
- Instability of Plasma and Serum Progastrin-Releasing Peptide During Repeated Freezing and Thawing
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Jae-Eun Lee, Jin-Hyun Lee, Maria Hong, Seul-Ki Park, Ji-In Yu, So-Youn Shin, Shine Young Kim
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Osong Public Health Res Perspect. 2016;7(6):351-355. Published online December 31, 2016
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Objectives
Progastrin-releasing peptide (proGRP) is a promising biomarker for small cell lung cancer. However, not much is known about how sample processing and storage conditions affect the stability of proGRP. Here, we examined the effects of repeated freeze–thaw cycles on the stability of proGRP in plasma and serum.
Methods
Concentrations of proGRP were measured in plasma and serum samples exposed to two, three,... |
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- Inorganic Phosphorus and Potassium Are Putative Indicators of Delayed Separation of Whole Blood
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Jae-Eun Lee, Maria Hong, Seul-Ki Park, Ji-In Yu, Jin-Sook Wang, Haewon Shin, Jong-Wan Kim, Bok-Ghee Han, So-Youn Shin
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Osong Public Health Res Perspect. 2016;7(2):90-95. Published online April 30, 2016
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Objectives
The delayed separation of whole blood can influence the concentrations of circulating blood components, including metabolites and cytokines. The aim of this study was to determine whether clinical-biochemistry analytes can be used to assess the delayed separation of whole blood.
Methods
We investigated the plasma and serum concentrations of five clinical-biochemistry analytes and free hemoglobin when the centrifugation of whole blood stored... |
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- Effect of Repeated Freezing and Thawing on Biomarker Stability in Plasma and Serum Samples
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Jae-Eun Lee, Shine Young Kim, So-Youn Shin
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Osong Public Health Res Perspect. 2015;6(6):357-362. Published online December 31, 2015
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Objectives
The stability of circulating proteins can be affected by repeated freezing and thawing. The aim of our study was to identify the effect of repeated freezing and thawing on the plasma and serum concentrations of eight proteins [interferon-γ, interleukin (IL)-8, IL-15, IL-17A, matrix metalloproteinase (MMP)-7, tumor necrosis factor-α, vascular endothelial growth factor (VEGF), and VEGF receptor 2 (VEGF-R2)].
Methods
We assessed the... |
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- Instability at Short Tandem Repeats in Lymphoblastoid Cell Lines
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Jae-Eun Lee, Eun-Jung Hong, Ji-Hyun Kim, So Youn Shin, Young-Youl Kim, Bok-Ghee Han
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Osong Public Health Res Perspect. 2013;4(4):194-196. Published online August 31, 2013
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Objectives
Epstein Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs) are a useful biological resource, however, genomic variations can happen during the generation and immortalization processes of LCLs. The purpose of this study was to identify genomic variations in LCL DNA compared with matched blood DNA using short tandem repeats (STRs) analysis.
Methods
We analyzed 15 STRs with blood DNA and their matched LCL... |
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- Articles
- National Biobank of Korea: Quality control Programs of Collected-human Biospecimens
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Jae-Eun Lee, Ji-Hyun Kim, Eun-Jung Hong, Hye Sook Yoo, Hye-Young Nam, Ok Park
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Osong Public Health Res Perspect. 2012;3(3):185-189. Published online June 30, 2012
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Personalized medicine is emerging as a main paradigm for risk prediction, pre-diagnosis, and effective prevention and treatment of disease. A large number of human biospecimens and their clinical data are essential resources for the success of personalized medicine as well as other biomedical research. The National Biobank of Korea (NBK) has collected well-annotated and high quality human biospecimens, and distributes... |
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