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Hyungmin Lee 4 Articles
A Healthcare-Associated Outbreak of HCV Genotype 2a at a Clinic in Seoul
Siwon Choi, Hyerim Lee, Hyungmin Lee, Yoon-Seok Chung
Osong Public Health Res Perspect. 2021;12(1):3-12.   Published online February 23, 2021
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  • 246 Download
AbstractAbstract PDF

An epidemiological investigation was conducted into a hepatitis C virus (HCV) outbreak at an outpatients clinic in Seoul (2011–2012). The aim of the study was to analyze the scale of infection, identify the source of infection, and route of transmission to prevent hepatitis C transmission in the future.


A retrospective study of the outpatients and health care workers (n = 7,285) in the target outpatient clinic during 2011–2012 was conducted. The history of the study population infection with hepatitis C, electronic medical records, field visits, and health care worker interviews were examined for the period between March 1st, 2006 and March 25th, 2016. The blood samples were collected and tested for anti-HCV antibodies, HCV RNA and HCV gene in 2016.


The rate of anti-HCV positive results was 4.4% in the study population. The risk factors associated with an anti-HCV positive result were ≥ 10 clinic visits, and receiving an invasive procedure including a nerve block and a block of the peripheral branch of the spinal nerve (p < 0.05). There were 112 HCV RNA positive cases out of 320 anti-HCV positive test result cases, amongst which 100 cases had the dominant HCV genotype 2a which formed either 1 cluster (n = 56) or 2 clusters (n = 25). This result indicated exposure to a high-association infection source.


Anti-HCV antibodies and genotypic analysis showed an epidemiological association between the outbreak of HCV and invasive procedures performed (2011–2012) at an outpatients clinic in Seoul.

A Study on the Relapse Rate of Tuberculosis and Related Factors in Korea Using Nationwide Tuberculosis Notification Data
Hyungmin Lee, Jusang Kim
Osong Public Health Res Perspect. 2014;5(Suppl):S8-S17.   Published online December 31, 2014
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  • 25 Download
  • 13 Crossref
AbstractAbstract PDF
From the perspective of public health, tuberculosis (TB) remains an important issue that threatens health. Korea is an intermediate burden country with a TB incidence of 97/100,000 individuals. Among many TB control measures, a relapse rate of TB is one indicator that can be used to indirectly assess the level of TB control in countries and in communities. Relapse TB has an approximately 12% yearly incidence in Korea. This study aims to estimate the relapse rate of TB and to investigate the associated factors by using nationwide TB notification data in Korea.
The nationwide TB notification data in 2005 was used with the exclusion criteria of duplicated reporting, foreign-born patients, outcome–died, and outcome–diagnosis changed. The data were double-checked as to whether they were reported again during 2006–2010 and the estimated relapse rate of TB. Associated factors were analyzed by multivariate logistic regression with the variables of age, sex, registration type, results of sputum smear test, medication, and outcome of treatment.
Among 45,434 TB patients in 2005, 4,371 patients were again reported as TB patients from 2006 to 2010. Five hundred and sixty-four patients were reported more than twice and the cumulative number of relapses was 5,072 cases. The 5-year relapse rate was estimated as 9.62%. The relapse rate decreased yearly: 4.8% in 2006, 2.4% in 2007, 1.6% in 2008, 1.4% in 2009, and 1.0% in 2010. Age, sex, registration type, tuberculosis type, and medication were independently associated with a relapse of TB. In the multivariate logistic regression analysis, the following factors were related: male sex, 40–49 years old; registration type, relapse, treatment after failure, treatment after default, transfer in, and other, the sputum smear-positive pulmonary TB, and medications (including individuals taking 2–5 drugs).
This study has estimated a 5-year relapse rate of TB in Korea that is slightly lower than the rate of relapse TB in the annual reports. This study could be conducted and cross-checked with data from the National Health Insurance in the future.


Citations to this article as recorded by  
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    Dararat Eksombatchai, Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Hongjo Choi, Young Ae Kang
    International Journal of Infectious Diseases.2023; 127: 1.     CrossRef
  • Recurrence of pulmonary tuberculosis in India: Findings from the 2019–2021 nationwide community-based TB prevalence survey
    Prathiksha Giridharan, Sriram Selvaraju, Raghuram Rao, Kiran Rade, Kannan Thiruvengadam, Smita Asthana, Rakesh Balachandar, Sampada Dipak Bangar, Avi Kumar Bansal, Jyothi Bhat, Debjit Chakraborty, Vishal Chopra, Dasarathi Das, Shanta Dutta, Kangjam Rekha
    PLOS ONE.2023; 18(12): e0294254.     CrossRef
  • Risk factors associated with tuberculosis recurrence in South Korea determined using a nationwide cohort study
    Hin Moi Youn, Moon-Kyung Shin, Dawoon Jeong, Hee-Jin Kim, Hongjo Choi, Young Ae Kang, Jun Hyeok Lim
    PLOS ONE.2022; 17(6): e0268290.     CrossRef
  • Facteurs de risque de récurrence de tuberculose pulmonaire bactériologique confirmé à Kisangani (République démocratique du Congo)
    Catherine Marie Nomopuane Kabudri, Shadrack Kandala Ngianga II, Léon Okenge Ngongo
    Santé Publique.2022; Vol. 34(4): 591.     CrossRef
  • Predicting the impact of control strategies on the tuberculosis burden in South and North Korea using a mathematical model
    Hyunwoo Cho, Youngmok Park, Jeongjoo Seok, Joon Sup Yeom, Jun Yong Choi, Hee Jin Kim, Young Ae Kang, Jeehyun Lee
    BMJ Global Health.2021; 6(10): e005953.     CrossRef
  • Preferred product characteristics for therapeutic vaccines to improve tuberculosis treatment outcomes: Key considerations from World Health Organization consultations
    Johan Vekemans, Michael James Brennan, Mark Hatherill, Lewis Schrager, Bernard Fritzell, Kathryn Rutkowski, Beatrice De Vos, Matteo Zignol, Georges Thiry, Ann M. Ginsberg, Barry Walker
    Vaccine.2020; 38(2): 135.     CrossRef
  • Rate and risk factors of recurrent tuberculosis in Yemen: a 5-year prospective study
    Mohammed Saif Anaam, Alian A. Alrasheedy, Saud Alsahali, Saeed O. Alfadly, Adel H. Aldhubhani
    Infectious Diseases.2020; 52(3): 161.     CrossRef
  • Small Animal Model of Post-chemotherapy Tuberculosis Relapse in the Setting of HIV Co-infection
    Matthew B. Huante, Tais B. Saito, Rebecca J. Nusbaum, Kubra F. Naqvi, Sadhana Chauhan, Robert L. Hunter, Jeffrey K. Actor, Jai S. Rudra, Mark A. Endsley, Joshua G. Lisinicchia, Benjamin B. Gelman, Janice J. Endsley
    Frontiers in Cellular and Infection Microbiology.2020;[Epub]     CrossRef
  • Proteomic analysis of infected primary human leucocytes revealed PSTK as potential treatment-monitoring marker for active and latent tuberculosis
    Benjawan Kaewseekhao, Sittiruk Roytrakul, Yodying Yingchutrakul, Kanin Salao, Wipa Reechaipichitkul, Kiatichai Faksri, HASNAIN SEYED EHTESHAM
    PLOS ONE.2020; 15(4): e0231834.     CrossRef
  • The association between proton pump inhibitor use and the risk of tuberculosis: A case‐control study
    Hyun Jin Song, Haesuk Park, Susan Park, Jin‐Won Kwon
    Pharmacoepidemiology and Drug Safety.2019; 28(6): 830.     CrossRef
  • Recurrence of tuberculosis in a low-incidence setting: a retrospective cross-sectional study augmented by whole genome sequencing
    Laila Parvaresh, Taryn Crighton, Elena Martinez, Andrea Bustamante, Sharon Chen, Vitali Sintchenko
    BMC Infectious Diseases.2018;[Epub]     CrossRef
  • Treatment Outcomes of Patients Treated for Pulmonary Tuberculosis after Undergoing Gastrectomy
    In Young Jung, Moo Hyun Kim, Woo Yong Jeong, Mi Young Ahn, Yong Duk Jeon, Hea Won Ahn, Jin Young Ahn, Je Eun Song, Dong Hyun Oh, Yong Chan Kim, Eun Jin Kim, Su Jin Jeong, Nam Su Ku, June Myung Kim, Jun Yong Choi
    The Tohoku Journal of Experimental Medicine.2016; 240(4): 281.     CrossRef
  • Is Tuberculosis Still the Number One Infectious Disease in Korea?
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2014; 5: S1.     CrossRef
Emerging Pathogens and Vehicles of Food- and Water-borne Disease Outbreaks in Korea, 2007–2012
Shinje Moon, Il-Woong Sohn, Yeongseon Hong, Hyungmin Lee, Ji-Hyuk Park, Geun-Yong Kwon, Sangwon Lee, Seung-Ki Youn
Osong Public Health Res Perspect. 2014;5(1):34-39.   Published online February 28, 2014
  • 3,232 View
  • 21 Download
  • 17 Crossref
AbstractAbstract PDF
Food- and water-borne disease outbreaks (FBDOs) are an important public health problem worldwide. This study investigated the trends in FBDOs in Korea and established emerging causal pathogens and causal vehicles.
We analyzed FBDOs in Korea by year, location, causal pathogens, and causal vehicles from 2007 to 2012. Information was collected from the FBDOs database in the Korean Centers for Disease Control and Prevention.
During 2007–2012, a total of 1794 FBDOs and 48,897 patients were reported. After 2007, FBDOs and patient numbers steadily decreased over the next 2 years and then plateaued until 2011. However, in 2012, FBDOs increased slightly accompanied by a large increase in the number of affected patients. Our results highlight the emergence of norovirus and pathogenic Escherichia coli other than enterohemorrhagic E. coli (EHEC) in schools in 2012. We found that pickled vegetables is an emerging causal vehicle responsible for this problem.
On the basis of this study we recommend intensified inspections of pickled vegetable manufacturers and the strengthening of laboratory surveillance of relevant pathogens.


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  • Measures for preventing norovirus outbreaks on campus in economically underdeveloped areas and countries: evidence from rural areas in Western China
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    Frontiers in Public Health.2024;[Epub]     CrossRef
  • Phage biocontrol of zoonotic food-borne pathogen Vibrio parahaemolyticus for seafood safety
    Jung Hyen Lee, Minjin Oh, Byoung Sik Kim
    Food Control.2023; 144: 109334.     CrossRef
  • Vibrio-infecting bacteriophages and their potential to control biofilm
    Ana Cevallos-Urena, Jeong Yeon Kim, Byoung Sik Kim
    Food Science and Biotechnology.2023; 32(12): 1719.     CrossRef
  • Antibiotic Resistance Profiles of Bacteria Isolated from Hotspot Environments in Bahir Dar City, Northwestern Ethiopia
    Kindu Geta, Mulugeta Kibret
    Journal of Multidisciplinary Healthcare.2022; Volume 15: 1403.     CrossRef
  • Inhibitory Effects of Crude Fucoidan Extract from Hizikia fusiformis against Norovirus Causing Foodborne Disease
    Hyojin Kim, Mi Sook Chung
    Korean Journal of Food and Cookery Science.2018; 34(5): 519.     CrossRef
  • High level of drug resistance by gram-negative bacteria from selected sewage polluted urban rivers in Addis Ababa, Ethiopia
    Teshome Belachew, Amete Mihret, Tesfaye Legesse, Yihenew Million, Kassu Desta
    BMC Research Notes.2018;[Epub]     CrossRef
  • Inhibitory Effects of Allium chinense and Its Dimethyl Disulfide against Murine Norovirus as a Surrogate for Foodborne Virus
    Mi Sook Chung
    Korean Journal of Food and Cookery Science.2018; 34(2): 222.     CrossRef
  • Inactivation of norovirus surrogates by kimchi fermentation in the presence of black raspberry
    Garam Bae, Jeongwon Kim, Hyojin Kim, Jong Hyeon Seok, Dan Bi Lee, Kyung Hyun Kim, Mi Sook Chung
    Food Control.2018; 91: 390.     CrossRef
  • Metagenomic Sequencing for Surveillance of Food- and Waterborne Viral Diseases
    David F. Nieuwenhuijse, Marion P. G. Koopmans
    Frontiers in Microbiology.2017;[Epub]     CrossRef
  • Prevalence, antimicrobial resistance and multiple-locus variable-number tandem-repeat analysis profiles of diarrheagenic Escherichia coli isolated from different retail foods
    Lili Wang, Hiromi Nakamura, Eriko Kage-Nakadai, Yukiko Hara-Kudo, Yoshikazu Nishikawa
    International Journal of Food Microbiology.2017; 249: 44.     CrossRef
  • Complete genome sequence ofVibrio parahaemolyticusFORC_023 isolated from raw fish storage water
    Han Young Chung, Eun Jung Na, Kyu-Ho Lee, Sangryeol Ryu, Hyunjin Yoon, Ju-Hoon Lee, Hyeun Bum Kim, Heebal Kim, Sang Ho Choi, Bong-Soo Kim, David Rasko
    Pathogens and Disease.2016; 74(4): ftw032.     CrossRef
  • An outbreak of norovirus infection associated with fermented oyster consumption in South Korea, 2013
    H. G. CHO, S. G. LEE, M. Y. LEE, E. S. HUR, J. S. LEE, P. H. PARK, Y. B. PARK, M. H. YOON, S. Y. PAIK
    Epidemiology and Infection.2016; 144(13): 2759.     CrossRef
  • Molecular epidemiology of norovirus in South Korea
    Sung-Geun Lee, Han-Gil Cho, Soon-Young Paik
    BMB Reports .2015; 48(2): 61.     CrossRef
  • Three Gastroenteritis Outbreaks in South Korea Caused by the Consumption of Kimchi Tainted by Norovirus GI.4
    Ji-Hyuk Park, Sunyoung Jung, Jaeseung Shin, Jeong Su Lee, In Sun Joo, Deog-Yong Lee
    Foodborne Pathogens and Disease.2015; 12(3): 221.     CrossRef
  • Environmental monitoring of bacterial contamination and antibiotic resistance patterns of the fecal coliforms isolated from Cauvery River, a major drinking water source in Karnataka, India
    Sinosh Skariyachan, Arpitha Badarinath Mahajanakatti, Nisha Jayaprakash Grandhi, Akshatha Prasanna, Ballari Sen, Narasimha Sharma, Kiran S Vasist, Rajeswari Narayanappa
    Environmental Monitoring and Assessment.2015;[Epub]     CrossRef
  • Detection of viable murine norovirus using the plaque assay and propidium-monoazide-combined real-time reverse transcription-polymerase chain reaction
    Minhwa Lee, Dong Joo Seo, Jina Seo, Hyejin Oh, Su Been Jeon, Sang-Do Ha, Jinjong Myoung, In-Soo Choi, Changsun Choi
    Journal of Virological Methods.2015; 221: 57.     CrossRef
  • Emergence of Norovirus GII.4 variants in acute gastroenteritis outbreaks in South Korea between 2006 and 2013
    Han-Gil Cho, Po-Hyun Park, Sung-Geun Lee, Ju-Eun Kim, Kyung-A Kim, Hyeun-Kyong Lee, Eun-Mi Park, Myong-Ki Park, Sun-Young Jung, Deog-Yong Lee, Mi-hye Yoon, Jong-Bok Lee, Soon-Young Paik
    Journal of Clinical Virology.2015; 72: 11.     CrossRef
Trends in the Incidence of Scrub Typhus: The Fastest Growing Vector-Borne Disease in Korea
Mi Ae Jeong, Seung-Ki Youn, Young-Kwon Kim, Hyungmin Lee, Sun-Ja Kim, Aeree Sohn
Osong Public Health Res Perspect. 2013;4(3):166-169.   Published online June 30, 2013
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  • 23 Download
  • 17 Crossref
AbstractAbstract PDF
Scrub typhus, also called tsutsugamushi disease, is classified as a Group 3 disease in Korea according to the National Notifiable Diseases Surveillance Systems. It is an infectious disease transmitted to humans through the bite of mites that are infected with an intracellular parasite called Orientia tsutsugamushi (Family: Rickettsiaceae). This study aims to identify the demographic characteristics of the infected cases according to profession, region, gender, and onset period and provide a basic data for prevention and control of the disease in the infected patients. Between 2001 and 2010, 16,741 men (36.3%) and 29,373 women (63.7%) were reported to have been infected with scrub typhus, with men being 1.6 times less infected than women. When classified according to age, it was found that 4421 persons (9.6%) were under 40 years of age; 6601 (13.1%) in their 40s; 9714 (21.1%) in their 50s; 13,067 (28.3%) in 60s; 10,128 (22.0%) in their 70s; and 2723 (5.9%) aged 80 or more. The elderly (60 years or older) represented more than half of the infected cases. When the infections were classified according to region, it was found that the county residents had the major share of infection, with a total of 1583 infected cases (59.85).


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    Se‐Jin Jeong, Jin‐Hwan Jeon, Kyung won Hwang
    Entomological Research.2023; 53(7): 247.     CrossRef
  • Epidemiological Aspects of Tsutsugamushi Disease (Scrub Typhus) Outbreaks in Republic of Korea and Japan
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    The Korean Journal of Aerospace and Environmental .2022; 32(2): 65.     CrossRef
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    Expert Review of Anti-infective Therapy.2021; 19(12): 1519.     CrossRef
  • Seropositivity of Scrub Typhus Inpatients Attending a Tertiary Care Hospital in Western Odisha
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    Journal of Evolution of Medical and Dental Science.2020; 9(04): 178.     CrossRef
  • Clinical and Laboratory Predictors associated with Complicated Scrub Typhus
    Mi-Hee Kim, Si-Hyun Kim, Jung-Hyun Choi, Seong-Heon Wie
    Infection & Chemotherapy.2019; 51(2): 161.     CrossRef
  • Molecular Epidemiology of an Orientia tsutsugamushi Gene Encoding a 56-kDa Type-Specific Antigen in Chiggers, Small Mammals, and Patients from the Southwest Region of Korea
    Jung Wook Park, Sun Hee Kim, Duck Woong Park, So Hyang Jung, Hye Jung Park, Mi Hee Seo, Hyeon Je Song, Jung Yoon Lee, Dong Min Kim, Choon-Mee Kim, Byong Chul Gill, Hang Jin Jeong, Jeong Min Lee, Dong Ryong Ha, Eun Sun Kim, Jae Keun Chung
    The American Journal of Tropical Medicine and Hygi.2018; 98(2): 616.     CrossRef
  • Clinical Aspects of Scrub Typhus Initially Misdiagnosed as Kawasaki Disease
    Sung Hoon Kim, Hae Jeong Lee, Ju Suk Lee
    Iranian Journal of Pediatrics.2018;[Epub]     CrossRef
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    Paul Trowbridge, Divya P., Prasanna S. Premkumar, George M. Varghese
    Tropical Medicine & International Health.2017; 22(5): 576.     CrossRef
  • Central Nervous System Infection Associated with Orientia tsutsugamushi in South Korea
    Kon Chu, Seon-Jae Ahn, Woo-Jin Lee, Jin-Sun Jun, Jung-Ah Lim, Keun-Hwa Jung, Kyung-Il Park, Jun-Sang Sunwoo, Han Sang Lee, Sang Kun Lee, Ki-Young Jung, Jangsup Moon, Soon-Tae Lee
    The American Journal of Tropical Medicine and Hygi.2017; 97(4): 1094.     CrossRef
  • Generation of protective immunity against Orientia tsutsugamushi infection by immunization with a zinc oxide nanoparticle combined with ScaA antigen
    Na-Young Ha, Hyun Mu Shin, Prashant Sharma, Hyun Ah Cho, Chan-Ki Min, Hong-il Kim, Nguyen Thi Hai Yen, Jae-Seung Kang, Ik-Sang Kim, Myung-Sik Choi, Young Keun Kim, Nam-Hyuk Cho
    Journal of Nanobiotechnology.2016;[Epub]     CrossRef
  • Immunization with an Autotransporter Protein of Orientia tsutsugamushi Provides Protective Immunity against Scrub Typhus
    Na-Young Ha, Prashant Sharma, Gwanghun Kim, Yuri Kim, Chan-Ki Min, Myung-Sik Choi, Ik-Sang Kim, Nam-Hyuk Cho, David H Walker
    PLOS Neglected Tropical Diseases.2015; 9(3): e0003585.     CrossRef
  • Current situation of scrub typhus in South Korea from 2001–2013
    Hyeong-Woo Lee, Pyo Yun Cho, Sung-Ung Moon, Byoung-Kuk Na, Yoon-Joong Kang, Youngjoo Sohn, Seung-Ki Youn, Yeongseon Hong, Tong-Soo Kim
    Parasites & Vectors.2015;[Epub]     CrossRef
  • 18F-FDG PET/CT Findings of Scrub Typhus
    Jahae Kim, Seong Young Kwon, Sae-Ryung Kang, Sang-Geon Cho, Ho-Chun Song
    Clinical Nuclear Medicine.2015; 40(10): e484.     CrossRef
  • Epidemiology of Scrub Typhus and the Eschars Patterns in South Korea from 2008 to 2012
    Ji-Hyuk Park, Sun-Ja Kim, Seung-Ki Youn, Kisoo Park, Jin Gwack
    Japanese Journal of Infectious Diseases.2014; 67(6): 458.     CrossRef

PHRP : Osong Public Health and Research Perspectives