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Hak Sung Lee

1 Article

Original Article

Ingenol Protects Human T Cells From HIV-1 Infection

Kee-Jong Hong, Hak Sung Lee, Yeong-shik Kim, Sung Soon Kim

Osong Public Health Res Perspect. 2011;2(2):109-114. Published online June 30, 2011

Cited By 10

Objectives Many natural compounds have been investigated as drug candidates to prevent human immunodeficiency virus (HIV) with low cytotoxicity. We tested whether ingenol from Euphorbia ingens exerts anti-HIV effects in human T cell lines. Methods and Results Ingenol effectively maintained high cell viability (CD₅₀, >1 mM) in H9 and MT4 T cells. The efficacy of ingenol to inhibit HIV-1 infection was dose dependent. ED₅₀ for 100...

DOI: https://doi.org/10.1016/j.phrp.2011.07.001

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