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Hak Sung Lee

1 Article

Original Article

Ingenol Protects Human T Cells From HIV-1 Infection

Kee-Jong Hong, Hak Sung Lee, Yeong-shik Kim, Sung Soon Kim

Osong Public Health Res Perspect. 2011;2(2):109-114. Published online June 30, 2011

Cited By 8

Objectives Many natural compounds have been investigated as drug candidates to prevent human immunodeficiency virus (HIV) with low cytotoxicity. We tested whether ingenol from Euphorbia ingens exerts anti-HIV effects in human T cell lines. Methods and Results Ingenol effectively maintained high cell viability (CD₅₀, >1 mM) in H9 and MT4 T cells. The efficacy of ingenol to inhibit HIV-1 infection was dose dependent. ED₅₀ for 100...

DOI: https://doi.org/10.1016/j.phrp.2011.07.001

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