Osong Public Health and Research Perspectives

Hadi Ghazanfari

1 Article

Frequencies of CD4+ T Regulatory Cells and their CD25^high and FoxP3^high Subsets Augment in Peripheral Blood of Patients with Acute and Chronic Brucellosis: Abbas Bahador, Jamshid Hadjati, Niloofar Hassannejad, Hadi Ghazanfari, Mohammadreza Maracy, Sirous Jafari, Maryam Nourizadeh, Amirhooshang Nejadeh; Osong Public Health Res Perspect. 2014;5(3):161-168. Published online June 30, 2014; DOI: https://doi.org/10.1016/j.phrp.2014.04.008

2,309 View
15 Download
12 Citations

Objectives
Brucellosis remains one of the most common zoonotic diseases worldwide. In humans, brucellosis can be a serious, debilitating, and sometimes chronic disease. Different mechanisms can be postulated as to the basis for the induction of the chronic status of infectious diseases that T regulatory cells are one of the most important related mechanisms. The current study was designed to determine whether percentage of CD4+Treg cells and their CD25^high and FoxP3^high subpopulations in peripheral blood are changed in human brucellosis samples in comparison to a control group.
Methods
In total, 68 brucellosis patients (acute form: n = 43, chronic form: n = 25) and 36 healthy volunteers entered our study. After isolating of peripheral blood mononuclear cells, heparinized venous blood samples were obtained from both patients and healthy donors, CD4, CD25, and FoxP3 molecules were evaluated by two- and three-color flow cytometric methods.
Results
The results revealed a new finding in relation to Treg cells and human brucellosis. The numbers of CD4⁺Treg cells and their CD25^high and FoxP3^high subsets increase significantly in the peripheral blood of acute and chronic forms of brucellosis samples compared with healthy groups, with this increase being greater in the chronic group.
Conclusion
There seems to be a correlation between increase of CD4+Treg cells and their subsets and the disease progress from healthy state to acute and chronic brucellosis.

Citations

Citations to this article as recorded by

Investigation of IL-35 and IL-39, New Members of the IL-12 Family, in Different Clinical Presentations of Brucellosis
Pınar Hız Ellergezen, Muhammed Ali Kizmaz, Abdurrahman Simsek, Nesrin Demir, Eren Cagan, S. Haldun Bal, E. Halis Akalin, H. Barbaros Oral, Ferah Budak
Immunological Investigations.2023; 52(3): 286. CrossRef
In obese hypertensives cholecalciferol inhibits circulating TH17 cells but not macrophage infiltration on adipose tissue
Catarina Santos, Andreia Monteiro, Ricardo Rodrigues, Catarina Ferreira, Joana Coutinho, Rui Filipe, Sância Ramos, Miguel Castelo Branco, Mafalda Fonseca
Clinical Immunology.2023; 247: 109244. CrossRef
The mechanism of chronic intracellular infection with Brucella spp.
Xiaoyi Guo, Hui Zeng, Mengjuan Li, Yu Xiao, Guojing Gu, Zhenhui Song, Xuehong Shuai, Jianhua Guo, Qingzhou Huang, Bo Zhou, Yuefeng Chu, Hanwei Jiao
Frontiers in Cellular and Infection Microbiology.2023;[Epub] CrossRef
The potential role of infusions of T regulatory cells in inducing and maintaining liver allograft tolerance
Jihad Aljabban, William Burlingham, Michael R. Lucey
Clinical Liver Disease.2023;[Epub] CrossRef
Immunosuppressive Mechanisms in Brucellosis in Light of Chronic Bacterial Diseases
Joaquin Miguel Pellegrini, Jean-Pierre Gorvel, Sylvie Mémet
Microorganisms.2022; 10(7): 1260. CrossRef
Immune effects of CDK4/6 inhibitors in patients with HR+/HER2− metastatic breast cancer: Relief from immunosuppression is associated with clinical response
Fabio Scirocchi, Simone Scagnoli, Andrea Botticelli, Alessandra Di Filippo, Chiara Napoletano, Ilaria Grazia Zizzari, Lidia Strigari, Silverio Tomao, Enrico Cortesi, Aurelia Rughetti, Paolo Marchetti, Marianna Nuti
eBioMedicine.2022; 79: 104010. CrossRef
Cell-Mediated Therapies to Facilitate Operational Tolerance in Liver Transplantation
Samia D. Ellias, Ellen L. Larson, Timucin Taner, Scott L. Nyberg
International Journal of Molecular Sciences.2021; 22(8): 4016. CrossRef
Exploring cannabidiol effects on inflammatory markers in individuals with cocaine use disorder: a randomized controlled trial
Florence Morissette, Violaine Mongeau-Pérusse, Elie Rizkallah, Paméla Thébault, Stéphanie Lepage, Suzanne Brissette, Julie Bruneau, Simon Dubreucq, Emmanuel Stip, Jean-François Cailhier, Didier Jutras-Aswad
Neuropsychopharmacology.2021; 46(12): 2101. CrossRef
Effects of indoleamine 2, 3‐dioxygenase (IDO) silencing on immunomodulatory function and cancer‐promoting characteristic of adipose‐derived mesenchymal stem cells (ASCs)
Fahimeh Heidari, Mahboobeh Razmkhah, Vahid Razban, Nasrollah Erfani
Cell Biology International.2021; 45(12): 2544. CrossRef
Impact of immune checkpoint molecules on FoxP3+ Treg cells and related cytokines in patients with acute and chronic brucellosis
Hua-Li Sun, Xiu-Fang Du, Yun-Xia Tang, Guo-Qiang Li, Si-Yuan Yang, Ling-Hang Wang, Xing-Wang Li, Cheng-Jie Ma, Rong-Meng Jiang
BMC Infectious Diseases.2021;[Epub] CrossRef
Meta-Analysis of the Changes of Peripheral Blood T Cell Subsets in Patients with Brucellosis
Rongjiong Zheng, Songsong Xie, Shaniya Niyazi, Xiaobo Lu, Lihua Sun, Yan Zhou, Yuexin Zhang, Kai Wang
Journal of Immunology Research.2018; 2018: 1. CrossRef
Assessment of TGF-β and IL10 levels in human brucellosis
Mousa Mohammadnia-Afrouzi, Soheil Ebrahimpour
Current Issues in Pharmacy and Medical Sciences.2018; 31(1): 22. CrossRef

Author index