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Gyung Tae Chung 8 Articles
Genome Sequencing Analysis of Atypical Shigella flexneri Isolated in Korea
Nan-Ok Kim, Hae-young Na, Su-Mi Jung, Gyung Tae Chung, Hyo Sun Kawk, Sahyun Hong
Osong Public Health Res Perspect. 2017;8(1):78-85.   Published online February 28, 2017
DOI: https://doi.org/10.24171/j.phrp.2017.8.1.11
  • 2,860 View
  • 21 Download
  • 1 Citations
AbstractAbstract PDFSupplementary Material
Objectives

An atypical Shigella flexneri strain with a plural agglutination pattern [i.e., reacting not only with serum samples containing type antigen II but also with serum samples containing group antigens (3)4 and 7(8)] was selected for genome sequencing, with the aim of obtaining additional comparative information about such strains.

Methods

The genomic DNA of atypical S. flexneri strain NCCP 15744 was sequenced using an Ion Torrent PGM sequencing machine (Life Technologies, USA). The raw sequence data were preprocessed and reference-assembled in the CLC Assembly Cell software (version 4.0.6; CLC bio, USA).

Results

Ion Torrent sequencing produced 1,450,025 single reads with an average length of 144 bp, totaling ~209 Mbp. The NCCP 15744 genome is composed of one chromosome and four plasmids and contains a gtrX gene. Among the published genome sequences of S. flexneri strains, including 2457T, Sf301, and 2002017, strain NCCP 15744 showed high similarity with strain 2002017. The differences between NCCP 15744 and 2002017 are as follows: i) NCCP 15744 carries four plasmids whereas 2002017 carries five; ii) 19 genes (including CI, CII, and cro) were lost in the SHI-O genomic island of NCCP 15744 and six genes were gained as compared with strain 2002017.

Conclusion

Strain NCCP 15744 is genetically similar to 2002017, but these two strains have different multilocus sequence types and serotypes. The exact reason is unclear, but the 19 lost genes may be responsible for the atypical seroconversion of strain NCCP 15744.

Citations

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  • Genomic and proteomic characterization of two strains of Shigella flexneri 2 isolated from infants’ stool samples in Argentina
    Mónica F. Torrez Lamberti, Lucrecia C. Terán, Fabián E. Lopez, María de las Mercedes Pescaretti, Mónica A. Delgado
    BMC Genomics.2022;[Epub]     CrossRef
Surveillance of Bacillus cereus Isolates in Korea from 2012 to 2014
Su-Mi Jung, Nan-Ok Kim, Injun Cha, Hae-young Na, Gyung Tae Chung, Hyo Sun Kawk, Sahyun Hong
Osong Public Health Res Perspect. 2017;8(1):71-77.   Published online February 28, 2017
DOI: https://doi.org/10.24171/j.phrp.2017.8.1.10
  • 2,786 View
  • 32 Download
  • 2 Citations
AbstractAbstract PDF
Objectives

To investigate the prevalence and toxin production characteristics of non-emetic and emetic Bacillus cereus strains isolated via the laboratory surveillance system in Korea.

Methods

A total of 667 B. cereus strains were collected by the Korea National Research Institute of Health laboratory surveillance system from 2012 to 2014. The collected strains were analyzed by geographical region, season, patient age, and patient sex. Additionally, the prevalence rates of enterotoxin and emetic toxin genes were evaluated.

Results

The isolation rate of B. cereus strains increased during the summer, but the isolation rate was evenly distributed among patient age groups. Emetic toxin was produced by 20.2% of the isolated strains. The prevalence rates of five enterotoxin genes (entFM, nheA, cytK2, hblC, and bceT) were 85.0, 78.6, 44.5, 36.6, and 29.7%, respectively, among non-emetic strains and 77.8, 59.3, 17.8, 11.9 and 12.6%, respectively, among emetic strains. Thus, the prevalence rates of all five enterotoxin genes were lower in emetic B. cereus.

Conclusion

The prevalence of enterotoxin genes differed between non-emetic and emetic B. cereus strains. Among emetic B. cereus strains, the prevalence rates of two enterotoxin genes (cytK2 and hblC) were lower than those among the non-emetic strains. In both the emetic and non-emetic strains isolated in Korea, nheA and entFM were the most prevalent enterotoxin genes.

Citations

Citations to this article as recorded by  
  • Autoinducer-2 Could Affect Biofilm Formation by Food-Derived Bacillus cereus
    Nari Lee, Myo-Deok Kim, Min-Cheol Lim
    Indian Journal of Microbiology.2021; 61(1): 66.     CrossRef
  • Effects of Low-Temperature Drying with Intermittent Gaseous Chlorine Dioxide Treatment on Texture and Shelf-Life of Rice Cakes
    Timilehin Martins Oyinloye, Won Byong Yoon
    Processes.2020; 8(3): 375.     CrossRef
Occurrence of Norovirus GII.4 Sydney Variant-related Outbreaks in Korea
Sunyoung Jung, Bo-Mi Hwang, Hyun Ju Jeong, Gyung Tae Chung, Cheon-Kwon Yoo, Yeon-Ho Kang, Deog-Yong Lee
Osong Public Health Res Perspect. 2015;6(5):322-326.   Published online October 31, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.10.004
  • 1,937 View
  • 17 Download
  • 8 Citations
AbstractAbstract PDF
Human noroviruses are major causative agents of food and waterborne outbreaks of nonbacterial acute gastroenteritis. In this study, we report the epidemiological features of three outbreak cases of norovirus in Korea, and we describe the clinical symptoms and distribution of the causative genotypes. The incidence rates of the three outbreaks were 16.24% (326/2,007), 4.1% (27/656), and 16.8% (36/214), respectively. The patients in these three outbreaks were affected by acute gastroenteritis. These schools were provided unheated food from the same manufacturing company. Two genotypes (GII.3 and GII.4) of the norovirus were detected in these cases. Among them, major causative strains of GII.4 (Hu-jeju-47-2007KR-like) were identified in patients, food handlers, and groundwater from the manufacturing company of the unheated food. In the GII.4 (Hu-jeju-47-2007KR-like) strain of the norovirus, the nucleotide sequences were identical and identified as the GII.4 Sydney variant. Our data suggests that the combined epidemiological and laboratory results were closely related, and the causative pathogen was the GII.4 Sydney variant strain from contaminated groundwater.

Citations

Citations to this article as recorded by  
  • A systematic review and meta-analysis indicates a substantial burden of human noroviruses in shellfish worldwide, with GII.4 and GII.2 being the predominant genotypes
    Yijing Li, Liang Xue, Junshan Gao, Weicheng Cai, Zilei Zhang, Luobing Meng, Shuidi Miao, Xiaojing Hong, Mingfang Xu, Qingping Wu, Jumei Zhang
    Food Microbiology.2023; 109: 104140.     CrossRef
  • Molecular epidemiology of norovirus infections in children with acute gastroenteritis in 2017–2019 in Tianjin, China
    Yulian Fang, Yanzhi Zhang, Hong Wang, Ouyan Shi, Wei Wang, Mengzhu Hou, Lu Wang, Jinying Wu, Yu Zhao
    Journal of Medical Virology.2022; 94(2): 616.     CrossRef
  • Assessment of potential infectivity of human norovirus in the traditional Korean salted clam product “Jogaejeotgal” by floating electrode-dielectric barrier discharge plasma
    Eun Bi Jeon, Man-Seok Choi, Ji Yoon Kim, Eun Ha Choi, Jun Sup Lim, Jinsung Choi, Kwang Soo Ha, Ji Young Kwon, Sang Hyeon Jeong, Shin Young Park
    Food Research International.2021; 141: 110107.     CrossRef
  • Characterizing the effects of thermal treatment on human norovirus GII.4 viability using propidium monoazide combined with RT-qPCR and quality assessments in mussels
    Eun Bi Jeon, Man-Seok Choi, Ji Yoon Kim, Kwang Soo Ha, Ji Young Kwon, Sung Hyeon Jeong, Hee Jung Lee, Yeoun Joong Jung, Ji-Hyoung Ha, Shin Young Park
    Food Control.2020; 109: 106954.     CrossRef
  • Molecular epidemiology of genogroup II norovirus infections in acute gastroenteritis patients during 2014–2016 in Pudong New Area, Shanghai, China
    Caoyi Xue, Lifeng Pan, Weiping Zhu, Yuanping Wang, Huiqin Fu, Chang Cui, Lan Lu, Sun Qiao, Biao Xu
    Gut Pathogens.2018;[Epub]     CrossRef
  • Review: Epidemiological evidence of groundwater contribution to global enteric disease, 1948–2015
    Heather M. Murphy, Morgan D. Prioleau, Mark A. Borchardt, Paul D. Hynds
    Hydrogeology Journal.2017; 25(4): 981.     CrossRef
  • Change in Concentrations of Human Norovirus and Male-Specific Coliphage under Various Temperatures, Salinities, and pH Levels in Seawater
    Poong Ho Kim, Yong Soo Park, Kunbawui Park, Ji Young Kwon, Hong Sik Yu, Hee Jung Lee, Ji Hoe Kim, Tae Seek Lee
    Korean Journal of Fisheries and Aquatic Sciences.2016; 49(4): 454.     CrossRef
  • Norovirus outbreaks occurred in different settings in the Republic of Korea
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2015; 6(5): 281.     CrossRef
Epidemics of Norovirus GII.4 Variant in Outbreak Cases in Korea, 2004–2012
Sunyoung Jung, Hyun Ju Jeong, Bo-Mi Hwang, Cheon-Kwon Yoo, Gyung Tae Chung, Hyesook Jeong, Yeon-Ho Kang, Deog-Yong Lee
Osong Public Health Res Perspect. 2015;6(5):318-321.   Published online October 31, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.10.002
  • 2,016 View
  • 19 Download
  • 1 Citations
AbstractAbstract PDF
Norovirus GII.4 is recognized as a worldwide cause of nonbacterial outbreaks. In particular, the GII.4 variant occurs every 2–3 years according to antigenic variation. The aim of our study was to identify GII.4 variants in outbreaks in Korea during 2004–2012. Partial VP1 sequence of norovirus GII.4-related outbreaks during 2004–2012 was analyzed. The partial VP1 sequence was detected with reverse transcription-polymerase chain reaction, seminested polymerase chain reaction, and nucleotide sequence of 312-314 base pairs for phylogenetic comparison. Nine variants emerged in outbreaks, with the Sydney variant showing predominance recently. This predominance may persist for at least 3 years, although new variants may appear in Korea.

Citations

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  • Genotypic and Epidemiological Trends of Acute Gastroenteritis Associated with Noroviruses in China from 2006 to 2016
    Shu-Wen Qin, Ta-Chien Chan, Jian Cai, Na Zhao, Zi-Ping Miao, Yi-Juan Chen, She-Lan Liu
    International Journal of Environmental Research an.2017; 14(11): 1341.     CrossRef
Enteric Bacteria Isolated from Diarrheal Patients in Korea in 2014
Nan-Ok Kim, Su-Mi Jung, Hae-Young Na, Gyung Tae Chung, Cheon-Kwon Yoo, Won Keun Seong, Sahyun Hong
Osong Public Health Res Perspect. 2015;6(4):233-240.   Published online August 31, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.07.005
  • 2,066 View
  • 18 Download
  • 10 Citations
AbstractAbstract PDFSupplementary Material
Objectives
The aim of this study was to characterize the pathogens responsible for causing diarrhea according to season, region of isolation, patient age, and sex as well as to provide useful data for the prevention of diarrheal disease.
Methods
Stool specimens from 14,886 patients with diarrhea were collected to identify pathogenic bacteria from January 2014 to December 2014 in Korea. A total of 3,526 pathogenic bacteria were isolated and analyzed according to season, region of isolation, and the age and sex of the patient.
Results
The breakdown of the isolated pathogenic bacteria were as follows: Salmonella spp. 476 (13.5%), pathogenic Escherichia coli 777 (22.0%), Vibrio parahaemolyticus 26 (0.74%), Shigella spp. 13 (0.37%), Campylobacter spp. 215 (6.10%), Clostridium perfringens 508 (14.4%), Staphylococcus aureus 1,144 (32.4%), Bacillus cereus 356 (10.1%), Listeria monocytogenes 1 (0.03%), and Yersinia enterocolitica 10 (0.3%). The isolation rate trend showed the highest ratio in the summer season from June to September for most of the pathogenic bacteria except the Gram-positive bacteria. The isolation rate of most of the pathogenic bacteria by patient age showed highest ratio in the 0–19 year age range. For isolation rate by region, 56.2% were isolated from cities and 43.8% were isolated from provinces.
Conclusion
Hygiene education should be addressed for diarrheal disease-susceptible groups, such as those younger than 10 years, aged 10–19 years, and older than 70 years, and monitoring for the pathogens is still required. In addition, an efficient laboratory surveillance system for infection control should be continued.

Citations

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  • Prevalence, co-infection and seasonality of fecal enteropathogens from diarrheic cats in the Republic of Korea (2016–2019): a retrospective study
    Ye-In Oh, Kyoung-Won Seo, Do-Hyung Kim, Doo-Sung Cheon
    BMC Veterinary Research.2021;[Epub]     CrossRef
  • Genotyping and antimicrobial susceptibility of Clostridium perfringens isolated from dromedary camels, pastures and herders
    Mahmoud Fayez, Ibrahim Elsohaby, Theeb Al-Marri, Kamal Zidan, Ali Aldoweriej, Elham El-Sergany, Ahmed Elmoslemany
    Comparative Immunology, Microbiology and Infectiou.2020; 70: 101460.     CrossRef
  • Comparative Analysis of Aerotolerance, Antibiotic Resistance, and Virulence Gene Prevalence in Campylobacter jejuni Isolates from Retail Raw Chicken and Duck Meat in South Korea
    Jinshil Kim, Hyeeun Park, Junhyung Kim, Jong Hyun Kim, Jae In Jung, Seongbeom Cho, Sangryeol Ryu, Byeonghwa Jeon
    Microorganisms.2019; 7(10): 433.     CrossRef
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    Youn Jeong Kim, Ki-Ho Park, Dong-Ah Park, Joonhong Park, Byoung Wook Bang, Seung Soon Lee, Eun Jung Lee, Hyo-Jin Lee, Sung Kwan Hong, Yang Ree Kim
    Infection & Chemotherapy.2019; 51(2): 217.     CrossRef
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    Chizoba Mercy Enemchukwu, Angus Nnamdi Oli, Ebere Innocent Okoye, Nonye Treasure Ujam, Emmanuel O. Osazuwa, George Ogonna Emechebe, Kenneth Nchekwube Okeke, Christian Chukwuemeka Ifezulike, Obiora Shedrack Ejiofor, Jude Nnaemeka Okoyeh
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    Journal of Bacteriology and Virology.2018; 48(4): 113.     CrossRef
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    Reza Ranjbar, Mehrdad Halaji
    BMC Public Health.2018;[Epub]     CrossRef
  • The Epidemiological Influence of Climatic Factors on Shigellosis Incidence Rates in Korea
    Yeong-Jun Song, Hae-Kwan Cheong, Myung Ki, Ji-Yeon Shin, Seung-sik Hwang, Mira Park, Moran Ki, Jiseun Lim
    International Journal of Environmental Research an.2018; 15(10): 2209.     CrossRef
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    Jay Prakash Yadav, Suresh Chandra Das, Pankaj Dhaka, Deepthi Vijay, Manesh Kumar, Asish Kumar Mukhopadhyay, Goutam Chowdhury, Pranav Chauhan, Rahul Singh, Kuldeep Dhama, Satya Veer Singh Malik, Ashok Kumar
    Anaerobe.2017; 47: 120.     CrossRef
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    Jin Eui Kim, Young ju Lee
    Irish Veterinary Journal.2017;[Epub]     CrossRef
Corrigendum to “Investigation of Biofilm Formation and its Association with the Molecular and Clinical Characteristics of Methicillin-resistant Staphylococcus aureus” [Volume 4, Issue 5, October 2013, Pages 225–232]
Jeong-Ok Cha, Jae Il Yoo, Jung Sik Yoo, Hae-Sun Chung, Sun-Hee Park, Hwa Su Kim, Yeong Seon Lee, Gyung Tae Chung
Osong Public Health Res Perspect. 2014;5(2):116-116.   Published online April 30, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.04.002
  • 1,756 View
  • 19 Download
PDF
Investigation of Biofilm Formation and its Association with the Molecular and Clinical Characteristics of Methicillin-resistant Staphylococcus aureus
Jeong-Ok Cha, Jae Il Yoo, Jung Sik Yoo, Hae-Sun Chung, Sun-Hee Park, Hwa Su Kim, Yeong Seon Lee, Gyung Tae Chung
Osong Public Health Res Perspect. 2013;4(5):225-232.   Published online October 31, 2013
DOI: https://doi.org/10.1016/j.phrp.2013.09.001
  • 2,198 View
  • 13 Download
  • 46 Citations
AbstractAbstract PDF
Objectives
To investigate the biofilm-forming related factors against MRSA bloodstream isolates and evaluates their clinical features and treatment outcomes by biofilm production.
Methods
We collected 126 consecutive methicillin-resistant Staphylococcus aureus (MRSA) causing blood stream infections (BSIs) at 10 tertiary hospitals from 2007 to 2009. We investigated biofilm-forming ability using a microtiter plate assay, and molecular characteristics including multilocus sequence typing, staphylococcal cassette chromosome mec and accessory gene regulator types. We compared the clinical characteristics and outcomes of patients infected with biofilm-forming and non-biofilm-forming MRSA isolates.
Results
Of the 126 samples, 86 (68.3%), including 5 strong level (OD570 ≥ 1.0) and 81 weak level (0.2 ≤ OD570 < 1.0), had biofilm-forming capacity. Detection of fibronectinbinding protein in biofilm-forming strains was significantly higher than biofilm non-forming ones (p = 0.001) and three enterotoxin genes (sec-seg-sei) islands had a high frequency regardless of biofilm production. However, biofilm-forming strains were more likely to be multidrug resistant (three or more non-β-lactam antibiotics) than biofilm non-forming ones [79.2% vs. 59.2%, p = 0.015, odds ratio (OR) 2.629, 95% confidence interval (CI) 1.92–5.81]. Clinical features of patients with BSIs caused by biofilm-forming MRSA strains were more likely to be hospital onset [77.9% vs. 60.0%, p = 0.024, OR 2.434, 95% CI 1.11–5.33) and more frequently occurred in patients with use of invasive devices [85.7% vs. 61.2%, p = 0.002, OR 3.879, 95% CI 1.61–8.97]. The other clinical features were compared with the clinical outcomes of the two groups and were not significant (p > 0.05).
Conclusion
Biofilm-forming MRSA strains showed higher frequency of fnbB gene than biofilm non-forming ones and more incidence rates on particular genotypes. And, their patient's features were not significantly different between two groups in this study, except for several clinical factors.

Citations

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    Journal of Pathogens.2018; 2018: 1.     CrossRef
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    L. Asadpour
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Alterations of gyrA, gyrB, and parC and Activity of Efflux Pump in Fluoroquinolone-resistant Acinetobacter baumannii
Sunok Park, Kyeong Min Lee, Yong Sun Yoo, Jung Sik Yoo, Jae Il Yoo, Hwa Su Kim, Yeong Seon Lee, Gyung Tae Chung
Osong Public Health Res Perspect. 2011;2(3):164-170.   Published online December 31, 2011
DOI: https://doi.org/10.1016/j.phrp.2011.11.040
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AbstractAbstract PDF
Objectives
This study investigated the fluoroquinolone-resistant mechanism of 56 clinical cases of A baumannii infection from 23 non-tertiary hospitals, collected between 2004 and 2006.
Methods
Susceptibility testing was performed by broth microdilution and Epsilometer test. Analyses of quinolone resistance-determining region (QRDR) were done by sequencing. The activity of the efflux pump was measured using inhibitors.
Results
The sequences from selected 56 isolates were divided into seven groups (I-VII) on the basis of mutations in gyrA (S83L), parC (S80L, S80W and S84K) and gyrB (containing the novel mutations E679D, D644Y and A677V). The 27 isolates with triple mutations in gyrA, gyrB and parC (groups IV-VII) showed higher levels of resistance to ciprofloxacin (minimal inhibitory concentration [MIC] of 16-256 μg/mL) than the 26 isolates with double mutations in gyrA and parC (groups II and III, MIC of 8-64 μ g/mL; p < 0.05). Alterations in the efflux pump were observed in four isolates with the parC S80L mutation (group II) or E84K mutation (group VII), but no effect was observed in an isolate with the parC S80 W mutation (group III).
Conclusion
These results suggest that triple mutations in clinical isolates of A baumannii contribute to the development of high levels of resistance to fluoroquinolones and that mutations in parC S80L or E84K (groups II and VII) may contribute to alterations in efflux pump activity in A baumannii.

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PHRP : Osong Public Health and Research Perspectives