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Elham Aboualigalehdari 1 Article
Anti-biofilm Properties of Peganum harmala against Candida albicans
Elham Aboualigalehdari, Nourkhoda Sadeghifard, Morovat Taherikalani, Zaynab Zargoush, Zahra Tahmasebi, Behzad Badakhsh, Arman Rostamzad, Sobhan Ghafourian, Iraj Pakzad
Osong Public Health Res Perspect. 2016;7(2):116-118.   Published online April 30, 2016
DOI: https://doi.org/10.1016/j.phrp.2015.12.010
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  • 11 Citations
AbstractAbstract PDF
Objectives
Vaginitis still remains as a health issue in women. It is notable that Candida albicans producing biofilm is considered a microorganism responsible for vaginitis with hard to treat. Also, Peganum harmala was applied as an anti fungal in treatment for many infections in Iran. Therefore, this study goal to investigate the role of P. harmala in inhibition of biofilm formation in C. albicans.
Methods
So, 27 C. albicans collected from women with Vaginitis, then subjected for biofilm formation assay. P. harmala was applied as antibiofilm formation in C. albicans.
Results
Our results demonstrated that P. harmala in concentration of 12 μg/ml easily inhibited strong biofilm formation; while the concentrations of 10 and 6 μg/ml inhibited biofilm formation in moderate and weak biofilm formation C. albicans strains, respectively.
Conclusion
Hence, the current study presented P. harmala as antibiofilm herbal medicine for C. albicans; but in vivo study suggested to be performed to confirm its effectiveness.

Citations

Citations to this article as recorded by  
  • Antifungal Mechanisms of a Chinese Herbal Medicine, Cao Huang Gui Xiang, Against Candida Species
    Huizhen Yue, Xiaolong Xu, Shasha He, Xuran Cui, Yuhong Guo, Jingxia Zhao, Bing Peng, Qingquan Liu
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
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    Jamila Fakchich, Mostafa Elachouri
    Journal of Ethnopharmacology.2021; 267: 113200.     CrossRef
  • Improving health benefits with considering traditional and modern health benefits of Peganum harmala
    Mohamad Hesam Shahrajabian, Wenli Sun, Qi Cheng
    Clinical Phytoscience.2021;[Epub]     CrossRef
  • Phytomedicine from Middle Eastern Countries: An Alternative Remedy to Modern Medicine against Candida spp Infection
    Mohammad Zubair Alam, Mohd Sajjad Ahmad Khan, Jenny Wilkinson
    Evidence-Based Complementary and Alternative Medic.2021; 2021: 1.     CrossRef
  • In vitro and in vivo activity of Peganum harmala L. alkaloids against phytopathogenic bacteria
    Hanan A. Shaheen, Marwa Y. Issa
    Scientia Horticulturae.2020; 264: 108940.     CrossRef
  • Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens
    Rajeev K. Singla, Ashok K. Dubey
    Current Topics in Medicinal Chemistry.2019; 19(28): 2567.     CrossRef
  • Assessment of the Antimicrobial and Antioxidant Activities of Ziziphus lotus and Peganum harmala
    Leila Ait Abderrahim, Khaled Taïbi, Chahinez Ait Abderrahim
    Iranian Journal of Science and Technology, Transac.2019; 43(2): 409.     CrossRef
  • Evaluation of Biofilm Formation and Anti-biofilm Properties of Peganum Harmala and Crocus Sativus in Shigella Flexneri Clinical Isolates
    Mahsa Jalili, Mansour Amraei, Nourkhoda Sadeghifard, Sobhan Ghafourian
    The Open Microbiology Journal.2019; 13(1): 297.     CrossRef
  • PgTeL, the lectin found in Punica granatum juice, is an antifungal agent against Candida albicans and Candida krusei
    Pollyanna Michelle da Silva, Maiara Celine de Moura, Francis Soares Gomes, Danielle da Silva Trentin, Ana Patrícia Silva de Oliveira, Gabriela Souto Vieira de Mello, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rego, Luana Cassandra Breitenb
    International Journal of Biological Macromolecules.2018; 108: 391.     CrossRef
  • Antibiofilm activities of norharmane and its derivatives against Escherichia coli O157:H7 and other bacteria
    Jin-Hyung Lee, Yong-Guy Kim, Sang Hee Shim, Jintae Lee
    Phytomedicine.2017; 36: 254.     CrossRef
  • Synthesis of silver nanoparticles using Peganum harmala extract as a green route
    Matin Azizi, Sajjad Sedaghat, Kambiz Tahvildari, Pirouz Derakhshi, Ahad Ghaemi
    Green Chemistry Letters and Reviews.2017; 10(4): 420.     CrossRef

PHRP : Osong Public Health and Research Perspectives