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Barkha Modi 1 Article
Strategies to combat Gram-negative bacterial resistance to conventional antibacterial drugs: a review
Priyanka Bhowmik, Barkha Modi, Parijat Roy, Antarika Chowdhury
Osong Public Health Res Perspect. 2023;14(5):333-346.   Published online October 18, 2023
DOI: https://doi.org/10.24171/j.phrp.2022.0323
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  • 1 Web of Science
  • 3 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDF
The emergence of antimicrobial resistance raises the fear of untreatable diseases. Antimicrobial resistance is a multifaceted and dynamic phenomenon that is the cumulative result of different factors. While Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus and Clostridium difficile, were previously the most concerning issues in the field of public health, Gram-negative pathogens are now of prime importance. The World Health Organization’s priority list of pathogens mostly includes multidrug-resistant Gram-negative organisms particularly carbapenem-resistant Enterobacterales, carbapenem-resistant Pseudomonas aeruginosa, and extensively drug-resistant Acinetobacter baumannii. The spread of Gram-negative bacterial resistance is a global issue, involving a variety of mechanisms. Several strategies have been proposed to control resistant Gram-negative bacteria, such as the development of antimicrobial auxiliary agents and research into chemical compounds with new modes of action. Another emerging trend is the development of naturally derived antibacterial compounds that aim for targets novel areas, including engineered bacteriophages, probiotics, metal-based antibacterial agents, odilorhabdins, quorum sensing inhibitors, and microbiome-modifying agents. This review focuses on the current status of alternative treatment regimens against multidrug-resistant Gram-negative bacteria, aiming to provide a snapshot of the situation and some information on the broader context.

Citations

Citations to this article as recorded by  
  • Efficacy of new generation biosorbents for the sustainable treatment of antibiotic residues and antibiotic resistance genes from polluted waste effluent
    Barkha Madhogaria, Sangeeta Banerjee, Atreyee Kundu, Prasanta Dhak
    Infectious Medicine.2024; 3(1): 100092.     CrossRef
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    Maria Qubtia, Shazia Akram Ghumman, Sobia Noreen, Huma Hameed, Shazia Noureen, Rizwana Kausar, Ali Irfan, Pervaiz Akhtar Shah, Hafsa Afzal, Misbah Hameed, Mohammad Raish, Maria Rana, Ajaz Ahmad, Katarzyna Kotwica-Mojzych, Yousef A. Bin Jardan
    ACS Omega.2024; 9(10): 12146.     CrossRef
  • Progress and potentialities in wood extractives-based materials for active food packaging applications
    Eliana I. Fernández Sosa, Nanci Ehman, Fernando E. Felissia, M. Guadalupe Chaves, M. Cristina Area
    Food Bioscience.2024; 60: 104489.     CrossRef

PHRP : Osong Public Health and Research Perspectives