- The Occurrence and Risk Assessment of Exposure to Aflatoxin M1 in Ultra-High Temperature and Pasteurized Milk in Hamadan Province of Iran
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Amir Sasan Mozaffari Nejad, Ali Heshmati, Tayebe Ghiasvand
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Osong Public Health Res Perspect. 2019;10(4):228-233. Published online August 31, 2019
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DOI: https://doi.org/10.24171/j.phrp.2019.10.4.05
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 Abstract
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Objectives
Aflatoxins are a category of poisonous compounds found in most plants, milk and dairy products. The present research was carried out to detect the presence of aflatoxin M1 (AFM1) in samples of milk collected from Hamadan province, Iran.
Methods
Twenty five samples of ultra-high temperature (UHT) and 63 samples of pasteurized milk were collected and the amount of AFM1 was measured by an Enzyme-Linked Immunosorbent Assay method. In addition, the estimated daily intake (EDI) and hazard index (HI) of AFM1 was determined by the following equations:(EDI= mean concentration of AFM1 × daily consumption of milk/body weight; HI= EDI/Tolerance Daily Intake).
Results
AFM1 was detected in 21 (84%) UHT milk samples and in 55 (87.30%) pasteurized milk samples. Seven (28%) samples of UHT and 21 (33.33%) pasteurized milk samples had higher AFM1 content than the limit allowed in the European Union and Iranian National Standard Limits (0.05 μg/kg). None of the samples exceeded the US Food and Drug Administration limit (0.5 μg/kg) for AFM1. EDI and HI for AM1 through milk were 0.107 ng/kg body weight/day, and 0.535, respectively.
Conclusion
A significant percentage of milk produced by different factories in Iran (84% of UHT and 87.3% of pasteurized milk) was contaminated with AFM1. Therefore, more control and monitoring of livestock feeding in dairy companies may help reduce milk contamination with AFM1. As the HI value was lower than 1, it can be assumed that there was no risk of developing liver cancer due to milk consumption.
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Citations
Citations to this article as recorded by  - Seasonal variation and risk assessment of exposure to aflatoxin M1 in milk, yoghurt, and cheese samples from Ilam and Lorestan Provinces of Iran
Kousar Aghebatbinyeganeh, Mohammadhosein Movassaghghazani, Mohamed Fathi Abdallah
Journal of Food Composition and Analysis.2024; 128: 106083. CrossRef - Adıyaman İlinde Satışa Sunulan Çiğ Sütlerde Aflatoksin M1 Varlığının Araştırılması ve Potansiyel Risk Değerlendirmesi
Sinan Çilenti, Zozan Garip, Füsun Temamoğulları
Etlik Veteriner Mikrobiyoloji Dergisi.2024; 35(1): 70. CrossRef - An overview of regional mycotoxin contamination in Iranian food
Kousar Aghebatbinyeganeh, Mohamed F. Abdallah
Food and Humanity.2024; 3: 100370. CrossRef - Review, meta-analysis and carcinogenic risk assessment of aflatoxin M1 in different types of milks in Iran
Fatemeh Mortezazadeh, Fathollah Gholami-Borujeni
Reviews on Environmental Health.2023; 38(3): 511. CrossRef - Molecular identification and biocontrol of ochratoxigenic fungi and ochratoxin A in animal feed marketed in the state of Qatar
Fatma Ali Alsalabi, Zahoor Ul Hassan, Roda F. Al-Thani, Samir Jaoua
Heliyon.2023; 9(1): e12835. CrossRef - Risk assessments for the dietary intake aflatoxins in food: A systematic review (2016–2022)
Kiran Bhardwaj, Julie P. Meneely, Simon A. Haughey, Moira Dean, Patrick Wall, Guangtao Zhang, Bob Baker, Christopher T. Elliott
Food Control.2023; 149: 109687. CrossRef - A systematic literature review for aflatoxin M1 of various milk types in Iran: Human health risk assessment, uncertainty, and sensitivity analysis
Tooraj Massahi, Amir Kiani, Kiomars Sharafi, Behzad Karami Matin, Abdullah Khalid Omer, Gholamreza Ebrahimzadeh, Jalil Jaafari, Nazir Fattahi
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Environmental Monitoring and Assessment.2023;[Epub] CrossRef - Effect of basil seed and xanthan gum on physicochemical, textural, and sensory characteristics of low‐fat cream cheese
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Food Science & Nutrition.2023; 11(10): 6060. CrossRef - Evaluation of aflatoxin M1 content in milk and dairy products by high-performance liquid chromatography in Tehran, Iran
Nazanin SHABANSALMANİ, Mohammadhosein MOVASSAGHGHAZANİ
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Rhea Sanjiv Chhaya, John O'Brien, Enda Cummins
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Mahtab Einolghozati, Ali Heshmati, Freshteh Mehri
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Frontiers in Microbiology.2022;[Epub] CrossRef - The occurrence of aflatoxin M1 in doogh, kefir, and kashk in Hamadan, Iran
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Food Science and Technology.2022;[Epub] CrossRef - Characterization and mechanism of aflatoxin degradation by a novel strain of Trichoderma reesei CGMCC3.5218
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Microchemical Journal.2021; 167: 106326. CrossRef - Prevalence of aflatoxin M1 in pasteurized and ultra-high temperature (UHT) milk marketed in Dar es Salaam, Tanzania
F. Mwakosya Hilda, K. Mugula Jovin
African Journal of Microbiology Research.2021; 15(9): 461. CrossRef - Multi-mycotoxin occurrence in feed, metabolism and carry-over to animal-derived food products: A review
J. Tolosa, Y. Rodríguez-Carrasco, M.J. Ruiz, P. Vila-Donat
Food and Chemical Toxicology.2021; 158: 112661. CrossRef - Presence of Aflatoxin M1 in Commercial Milk in Paraguay
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Journal of Food Protection.2021; 84(12): 2128. CrossRef - The Occurrence and Risk Assessment of Aflatoxin M1 in Yoghurt Samples from Hamadan, Iran
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The Open Public Health Journal.2020; 13(1): 512. CrossRef
- Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains
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Firouzeh Farahtaj, Leila Alizadeh, Alireza Gholami, Alireza Tahamtan, Sadegh Shirian, Maryam Fazeli, Amir Sasan Mozaffari Nejad, Ali Gorji, Hamid Mahmoudzadeh Niknam, Amir Ghaemi
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Osong Public Health Res Perspect. 2019;10(1):6-11. Published online February 28, 2019
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DOI: https://doi.org/10.24171/j.phrp.2019.10.1.03
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9,063
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279
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12
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Abstract
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Objectives
Despite all the efforts and increased knowledge of rabies, the exact mechanisms of infection and mortality from the rabies virus are not well understood. To understand the mechanisms underlying the pathogenicity of rabies virus infection, it is crucial to study the tissue that the rabies virus naturally infects in humans.
Methods
Cerebellum brain tissue from 9 human post mortem cases from Iran, who had been infected with rabies virus, were examined histopathologically and immunohistochemically to evaluate the innate immune responses against the rabies virus.
Results
Histopathological examination revealed inflammation of the infected cerebellum and immunohistochemical analyses showed an increased immunoreactivity of heat shock protein 70, interleukin-6, interleukin-1, tumor necrosis factor-alpha, caspase-3, caspase-9, toll-like receptor3 and toll-like receptor4 in the infected brain tissue.
Conclusion
These results indicated the involvement of innate immunity in rabies infected human brain tissue, which may aggravate the progression of this deadly disease.
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Journal of Neuroscience Methods.2024; 405: 110085. CrossRef - Biosensor as an alternative diagnostic method for rabies virus detection: A literature review
Milad Zandi, Sajad Zandi, Ramin Mohammadi, Parastoo Hosseini, Samane Teymouri, Saber Soltani, Azadeh Rasouli
Biotechnology and Applied Biochemistry.2022; 69(4): 1348. CrossRef - Immunohistochemical diagnosis of human infectious diseases: a review
Hamadou Oumarou Hama, Gérard Aboudharam, Rémi Barbieri, Hubert Lepidi, Michel Drancourt
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Pulleri Kandi Harsha, Sathyanarayanan Ranganayaki, Gowri Yale, Gourav Dey, Kiran K. Mangalaparthi, Anusha Yarlagadda, B. K. Chandrasekhar Sagar, Anita Mahadevan, M. M. Srinivas Bharath, Reeta S. Mani
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Rabi Narayan Hota, Shalendra Singh, Rakesh Sharma, Pallavi Khandare
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Firouzeh Farahtaj, Alireza Gholami, Mohammad Sadeq Khosravy, Safoora Gharibzadeh, Hamid Mahmoudzadeh Niknam, Amir Ghaemi
Microbial Pathogenesis.2021; 157: 104971. CrossRef - Establishment of Human-Induced Pluripotent Stem Cell-Derived Neurons—A Promising In Vitro Model for a Molecular Study of Rabies Virus and Host Interaction
Thanathom Chailangkarn, Nathiphat Tanwattana, Thanakorn Jaemthaworn, Sira Sriswasdi, Nanchaya Wanasen, Sithichoke Tangphatsornruang, Kantinan Leetanasaksakul, Yuparat Jantraphakorn, Wanapinun Nawae, Penpicha Chankeeree, Porntippa Lekcharoensuk, Boonlert L
International Journal of Molecular Sciences.2021; 22(21): 11986. CrossRef - Beneficial and Detrimental Effects of Regulatory T Cells in Neurotropic Virus Infections
Malgorzata Ciurkiewicz, Vanessa Herder, Andreas Beineke
International Journal of Molecular Sciences.2020; 21(5): 1705. CrossRef - Characterization of the Th17 profile immune response in cases of human rabies transmitted by dogs and its interference in the disease pathogenesis.
L.B. Santos, F. Guedes, S.M. Achkar, M.I.S. Duarte, I.S.S. Katz, S.R. Silva, E.R. Fernandes
Journal of Neuroimmunology.2020; 344: 577263. CrossRef - Quantitative proteomics leads to identify dog brain proteins involved in rabies virus infection: implication in understanding viral pathophysiology
Suchismita Behera, Rajesh Raghunath Pharande, R. Rajendra Reddy, Sharmila B. Majee, Sandeepan Mukherjee, Amol Ratnakar Suryawanshi
Journal of Proteins and Proteomics.2020; 11(4): 241. CrossRef - Feral dog bite causing paralytic rabies: Difficult diagnosis and failure of prevention
Hussein Algahtani, Bader Shirah, Emna Chtourou, Osama Abuhawi, Nawal Abdelghaffar, Mohammad Alshehri
Saudi Journal for Health Sciences.2020; 9(3): 260. CrossRef
- Factors that Correlate with Poor Glycemic Control in Type 2 Diabetes Mellitus Patients with Complications
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Mohammad Haghighatpanah, Amir Sasan Mozaffari Nejad, Maryam Haghighatpanah, Girish Thunga, Surulivelrajan Mallayasamy
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Osong Public Health Res Perspect. 2018;9(4):167-174. Published online August 31, 2018
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DOI: https://doi.org/10.24171/j.phrp.2018.9.4.05
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11,413
View
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210
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74
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Abstract
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Objectives
Inadequate glycemic control amongst patients with Type 2 diabetes mellitus (T2DM) indicates a major public health problem and a significant risk factor for the progression and complications caused by diabetes. Glycemic control is the main therapeutic objective for the prevention of organ damage and other complications arising from diabetes.
Methods
This was a retrospective observational study of T2DM patients with complications, who were aged 40 years and older. The study was conducted retrospectively on medical records (in-patient and out-patient) obtained from a South Indian teaching hospital, Manipal, India. The patients included in the study had fasting blood sugar, postprandial blood sugar and HbA1c measured at least twice during follow-ups the previous year. Patients’ HbA1c levels were categorized into good control ≤7% (≤53mmol/mol), and poor control >7% (>53mmol/mol), and patients’ characteristics were analyzed.
Results
A total of 657 patients were included in the study. The mean age was 59.67 (SD = 9.617) years, with 152 (23.1%) females and 505 (76.9%) males, and 514 (78.2%) patients had poor glycemic control. Most of the patients were on insulin mono-therapy [n = 271 (42.1%)], about a third of the patients were on combination therapy that included an oral hypoglycemic agent and insulin [n = 236 (36.6%)]. Patients with a history of more than 10 years of diabetes [n = 293 (44.6%)], had a family history of diabetes [n = 256 (39%)] and obesity [n = 95 (14.5%)], all had poor glycemic control.
Conclusion
This present study indicated a significant association of gender (female), age, high-density lipoprotein level, duration of diabetes and type of medication, with poor glycemic control in T2DM patients that had secondary medical complications.
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Citations
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