Skip Navigation
Skip to contents

PHRP : Osong Public Health and Research Perspectives


Author index

Page Path
HOME > Articles and issues > Author index
Ahmad Valizadeh 1 Article
Effects of Fenugreek Seed Extract and Swimming Endurance Training on Plasma Glucose and Cardiac Antioxidant Enzymes Activity in Streptozotocin-induced Diabetic Rats
Sajad Arshadi, Salar Bakhtiyari, Karimeh Haghani, Ahmad Valizadeh
Osong Public Health Res Perspect. 2015;6(2):87-93.   Published online April 30, 2015
  • 2,658 View
  • 20 Download
  • 12 Citations
AbstractAbstract PDF
Objective Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia condition resulting from defective insulin secretion or resistance insulin action, or both. The purpose of this study was to evaluate the effect of 6 weeks swimming training and Trigonella foenum-graecum seed (fenugreek) extract, alone and in combination, on plasma glucose and cardiac antioxidant enzyme activity of streptozotocin-induced diabetic rats.
Fifty male Wistar rats were divided into five groups: diabetic control (DC, n = 8); healthy control (HC, n = 11); swimming training (S, n = 11); swimming training + fenugreek seed extract (1.74 g/kg body weight; SF1, n = 11); and swimming training + fenugreek seed extract (0.87 g/kg body weight; SF2, n = 9). Streptozotocin was used for the induction of diabetes. Results were analyzed using one-way analysis of variance followed by Tukey test.
In comparison with the DC group, all groups exhibited a significant decrease in body weight (p < 0.05), except for the HC group. SF1 and HC groups showed significant decreases in plasma glucose levels compared with the DC group (p < 0.05). S, SF1, SF2, and HC groups showed significant elevations in cardiac antioxidant enzymes activity in comparison with the DC group.
The results indicated that the combination of endurance swimming training and fenugreek seed extract can significantly reduce the plasma glucose levels and increase cardiac antioxidant enzymes activity in diabetic rats. Our findings suggest that this combination could be useful for the treatment of hyperglycemia and cardiac oxidative stress induced by diabetes mellitus.


Citations to this article as recorded by  
  • Safety and Efficacy of Furosap®, a Patented Trigonella foenum-graecum Seed Extract, in Boosting Testosterone Level, Reproductive Health and Mood Alleviation in Male Volunteers
    S. N. Sankhwar, Pawan Kumar, Manashi Bagchi, Mehul Rungta, Debasis Bagchi
    Journal of the American Nutrition Association.2023; 42(1): 27.     CrossRef
  • The toxic effects of anabolic steroids “nandrolone decanoate” on cardiac and skeletal muscles with the potential ameliorative effects of silymarin and fenugreek seeds extract in adult male albino rats
    Dalia Abd Elwahab Hassan, Sherien S. Ghaleb, Amr reda Zaki, Ahmed Abdelmenem, Shimaa Nabil, Mostafa Abdallah Abdel Alim
    BMC Pharmacology and Toxicology.2023;[Epub]     CrossRef
  • Fenugreek and Its Effects on Muscle Performance: A Systematic Review
    Waleed I. Albaker
    Journal of Personalized Medicine.2023; 13(3): 427.     CrossRef
  • The Impact of Chronic Stress on Behavior and Body Mass in New Animal Models
    Anisia Iuliana Alexa, Carmen Lăcrămioara Zamfir, Camelia Margareta Bogdănici, Andra Oancea, Alexandra Maștaleru, Irina Mihaela Abdulan, Daniel Constantin Brănișteanu, Alin Ciobîcă, Miruna Balmuș, Teodora Stratulat-Alexa, Roxana Elena Ciuntu, Florentina Se
    Brain Sciences.2023; 13(10): 1492.     CrossRef
  • Cardioprotective effects of exercise preconditioning on ischemia-reperfusion injury and ventricular ectopy in young and senescent rats
    Adnan Fatahi, Ebrahim Zarrinkalam, Kamal Azizbeigi, Kamal Ranjbar
    Experimental Gerontology.2022; 162: 111758.     CrossRef
  • Protective effects of medicinal plant against diabetes induced cardiac disorder: A review
    Sadegh Shabab, Zahra Gholamnezhad, Maryam Mahmoudabady
    Journal of Ethnopharmacology.2021; 265: 113328.     CrossRef
  • The Effects of Hydro-Alcoholic Extract of Fenugreek Seeds on the Lipid Profile and Oxidative Stress in Fructose-Fed Rats
    Maryam Mohammad-Sadeghipour, Mehdi Afsharinasab, Maryam Mohamadi, Mehdi Mahmoodi, Soudeh Khanamani Falahati-pour, Mohammad Reza Hajizadeh
    Journal of Obesity & Metabolic Syndrome.2020; 29(3): 198.     CrossRef
  • Dose-dependent effects of fenugreek seed extract on the biochemical and haematological parameters in high-fat diet-fed rats
    Takkella Nagamma, Anjaneyulu Konuri, Chandrika D. Nayak, Shobha U. Kamath, Padmanabha E.G. Udupa, Yogendra Nayak
    Journal of Taibah University Medical Sciences.2019; 14(4): 383.     CrossRef
  • A small plant with big benefits: Fenugreek (Trigonella foenum‐graecum Linn.) for disease prevention and health promotion
    Kalyan C. Nagulapalli Venkata, Anand Swaroop, Debasis Bagchi, Anupam Bishayee
    Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
  • Amelioration of Hyperglycemia and Associated Health Hazards Using Two Dietary Formulas Composed of Multiple Ingredients
    F.A. El-Shobaki, Amal S. Abdel-Azee, Amany M. Hegazy, Hassan Z. Hassouna, I.H. Badawy
    American Journal of Food Technology.2017; 12(4): 227.     CrossRef
  • State of hyperglycemic animals during consumption of high-calorie diet with the bionanocomposite supplement
    Ie. Goloborodko, V. Konopelniuk, L. Ostapchenko
    Bulletin of Taras Shevchenko National University o.2017; 22(1): 43.     CrossRef
  • In Vivo Effects of Quercetin in Association with Moderate Exercise Training in Improving Streptozotocin-Induced Aortic Tissue Injuries
    Irina Chis, Andrei Coseriu, Ramona Simedrea, Adrian Oros, Andras Nagy, Simona Clichici
    Molecules.2015; 20(12): 21770.     CrossRef

PHRP : Osong Public Health and Research Perspectives