- The Prevalence of CYP2B6 Gene Polymorphisms in Malaria-endemic Population of Timor in East Nusa Tenggara Indonesia
-
Linawati Hananta, Indwiani Astuti, Ahmad Hamim Sadewa, Josephine Alice, Jontari Hutagalung, Mustofa
-
Osong Public Health Res Perspect. 2018;9(4):192-196. Published online August 31, 2018
-
DOI: https://doi.org/10.24171/j.phrp.2018.9.4.08
-
-
4,756
View
-
43
Download
-
8
Citations
-
 Abstract
 PDF
-
Objectives
The CYP2B6 is one of the most polymorphic CYP genes in humans that has the potential to modify the pharmacological and toxicological responses to clinically important drugs such as antimalarial artemisinin and its derivatives. The aim of the study was to determine the frequency of CYP2B6 polymorphisms in Timor malaria endemic area, East Nusa Tenggara, Indonesia where Artemisin-based Combination Therapy (ACT) has been used to treat uncomplicated malaria.
Methods
A total of 109 healthy subjects were participated in this study. CYP2B6*4, *6 and *9 polymorphisms were analyzed using PCR-RFLP to confirm the SNPs prevalence of 516G>T and 785A>G in exon 4 and 5.
Results
There were 96 subjects included in the analysis. In the exon 4 of CYP2B6 516G>T, the frequency of the T mutation was 37.5% (39/96), and the wildtype 27.1% (26/96). In the exon 5, CYP2B6 785A>G mutant was detected in 29.2% (28/96) of individuals, and the wildtype allele in 35.4% (34/96). The frequency of CYP2B6*9 (516G>T), CYP2B6*4 (785A>G) and CYP2B6*6 (516G>T and 785A>G) were 40.6%, 29.2% and 22.9%, respectively. The prevalence of these CYP2B6 gene polymorphisms in Timorian ethnic were higher than that in Malay, Han Chinese, Indian, and Egyptian populations.
Conclusion
The prevalence of these CYP2B6 516G>T and 785A>G polymorphisms in Timorian ethnic is higher than that in other populations. These polymorphisms may affect the metabolism of artemisinin and its derivatives.
-
Citations
Citations to this article as recorded by  - Leveraging Mann–Whitney U test on large-scale genetic variation data for analysing malaria genetic markers
Kah Yee Tai, Jasbir Dhaliwal, Vinod Balasubramaniam
Malaria Journal.2022;[Epub] CrossRef - Frequency of CYP2B6 Alleles in Major Iranian Ethnicities, Affecting Response to Efavirenz
Parham Mardi, Bahareh Tavakoli-Far, Samira Sheibani Nia, Roshanak Jazayeri, Massoud Houshmand, Nadeem Sheikh
Genetics Research.2022; 2022: 1. CrossRef - Phenotyping Study of Cyclophosphamide 4-Hydroxylation in Malay Cancer Patients
Yesi Ihdina Fityatal Hasanah, Yahdiana Harahap, Denni Joko Purwanto
Drug Design, Development and Therapy.2021; Volume 15: 305. CrossRef - CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations—Implication for Drug Safety, Dosing, and Individualized Therapy
Immaculate M. Langmia, Katja S. Just, Sabrina Yamoune, Jürgen Brockmöller, Collen Masimirembwa, Julia C. Stingl
Frontiers in Genetics.2021;[Epub] CrossRef - The correlation between the level of 3-hydroxypropyl mercapturic acid, CYP2B6 polymorphisms, and hematuria occurrences after cyclophosphamide administration and its bioanalytical methods: A systematic review
Yahdiana Harahap, Farhan Nurahman, Denni Joko Purwanto, Arry Yanuar
Heliyon.2021; 7(10): e08126. CrossRef - Frequencies of CYP2B6∗4,∗5, and ∗6 Alleles within an Iranian Population (Mazandaran)
Mohammad Bagher Hashemi-Soteh, Elaheh Hosseini, Shokoufeh Fazelnia, Faramarz Ghasemian-Sorbeni, Sara Madahian, Mohammad Reza Shiran, Hafiz Ishfaq Ahmad
Genetics Research.2021; 2021: 1. CrossRef - In vitro and in silico Determination of the Interaction of Artemisinin with Human Serum Albumin
S. Ginosyan, H. Grabski, S. Tiratsuyan
Molecular Biology.2020; 54(4): 586. CrossRef - A Review of Danshen Combined with Clopidogrel in the Treatment of Coronary Heart Disease
Zhaojian Zhang, Yu Wang, Wangxiao Tan, Siwei Wang, Jinghua Liu, Xiao Liu, Xiaoying Wang, Xiumei Gao
Evidence-Based Complementary and Alternative Medic.2019; 2019: 1. CrossRef
|
