Osong Public Health and Research Perspectives

Ae Kyung Park

3 Articles

Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea: Jeong-Min Kim, Dongju Kim, Nam-Joo Lee, Sang Hee Woo, Jaehee Lee, Hyeokjin Lee, Ae Kyung Park, Jeong-Ah Kim, Chae Young Lee, Il-Hwan Kim, Cheon Kwon Yoo, Eun-Jin Kim; Osong Public Health Res Perspect. 2023;14(4):272-278. Published online July 27, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0024

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Objectives
Coronavirus disease 2019 (COVID-19) has been declared a global pandemic owing to the rapid spread of the causative agent, severe acute respiratory syndrome coronavirus 2. Its Delta and Omicron variants are more transmissible and pathogenic than other variants. Some debates have emerged on the mechanism of variants of concern. In the COVID-19 wave that began in December 2021, the Omicron variant, first reported in South Africa, became identifiable in most cases globally. The aim of this study was to provide data to inform effective responses to the transmission of the Omicron variant.
Methods
The Delta variant and the spike protein D614G mutant were compared with the Omicron variant. Viral loads from 5 days after symptom onset were compared using epidemiological data collected at the time of diagnosis.
Results
The Omicron variant exhibited a higher viral load than other variants, resulting in greater transmissibility within 5 days of symptom onset.
Conclusion
Future research should focus on vaccine efficacy against the Omicron variant and compare trends in disease severity associated with its high viral load.

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Replication kinetics and infectivity of SARS-CoV-2 Omicron variant sublineages recovered in the Republic of Korea
Jeong-Min Kim, Dongju Kim, Jee Eun Rhee, Cheon Kwon Yoo, Eun-Jin Kim
Osong Public Health and Research Perspectives.2024; 15(3): 260. CrossRef
Diagnostic Accuracy of the Abbott BinaxNOW COVID‐19 Antigen Card Test, Puerto Rico
Zachary J. Madewell, Chelsea G. Major, Nathan Graff, Cameron Adams, Dania M. Rodriguez, Tatiana Morales, Nicole A. Medina Lopes, Rafael Tosado, Liliana Sánchez‐González, Janice Perez‐Padilla, Hannah R. Volkman, Jorge Bertrán‐Pasarell, Diego Sainz de la Pe
Influenza and Other Respiratory Viruses.2024;[Epub] CrossRef

Results of contact tracing for SARS-CoV-2 Omicron sub-lineages (BA.4, BA.5, BA.2.75) and the household secondary attack risk: Mi Yu, Sang-Eun Lee, Hye Young Lee, Hye-jin Kim, Yeong-Jun Song, Jian Jeong, Ae Kyung Park, Il-Hwan Kim, Eun-jin Kim, Young-Joon Park; Osong Public Health Res Perspect. 2023;14(3):173-179. Published online June 22, 2023; DOI: https://doi.org/10.24171/j.phrp.2022.0285

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Graphical Abstract Abstract PDF

Objectives
This study aimed to assess the contact tracing outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sub-lineages BA.4, BA.5, and BA.2.75 within Republic of Korea, and to generate foundational data for responding to future novel variants.
Methods
We conducted investigations and contact tracing for 79 confirmed BA.4 cases, 396 confirmed BA.5 cases, and 152 confirmed BA.2.75 cases. These cases were identified through random sampling of both domestically confirmed and imported cases, with the goal of evaluating the pattern of occurrence and transmissibility.
Results
We detected 79 instances of Omicron sub-lineage BA.4 across a span of 46 days, 396 instances of Omicron sub-lineage BA.5 in 46 days, and 152 instances of Omicron sub-lineage BA.2.75 over 62 days. One patient with severe illness was confirmed among the BA.5 cases; however, there were no reports of severe illness in the confirmed BA.4 and BA.2.75 cases. The secondary attack risk among household contacts were 19.6% for BA.4, 27.8% for BA.5, and 24.3% for BA.2.75. No statistically significant difference was found between the Omicron sub-lineages.
Conclusion
BA.2.75 did not demonstrate a higher tendency for transmissibility, disease severity, or secondary attack risk within households when compared to BA.4 and BA.5. We will continue to monitor major SARS-CoV-2 variants, and we plan to enhance the disease control and response systems.

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Replication kinetics and infectivity of SARS-CoV-2 Omicron variant sublineages recovered in the Republic of Korea
Jeong-Min Kim, Dongju Kim, Jee Eun Rhee, Cheon Kwon Yoo, Eun-Jin Kim
Osong Public Health and Research Perspectives.2024; 15(3): 260. CrossRef

Genomic Surveillance of SARS-CoV-2: Distribution of Clades in the Republic of Korea in 2020: Ae Kyung Park, Il-Hwan Kim, Junyoung Kim, Jeong-Min Kim, Heui Man Kim, Chae young Lee, Myung-Guk Han, Gi-Eun Rhie, Donghyok Kwon, Jeong-Gu Nam, Young-Joon Park, Jin Gwack, Nam-Joo Lee, SangHee Woo, Jin Sun No, Jaehee Lee, Jeemin Ha, JeeEun Rhee, Cheon-Kwon Yoo, Eun-Jin Kim; Osong Public Health Res Perspect. 2021;12(1):37-43. Published online February 23, 2021; DOI: https://doi.org/10.24171/j.phrp.2021.12.1.06

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Abstract PDF

Since a novel beta-coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019, there has been a rapid global spread of the virus. Genomic surveillance was conducted on samples isolated from infected individuals to monitor the spread of genetic variants of SARS-CoV-2 in Korea. The Korea Disease Control and Prevention Agency performed whole genome sequencing of SARS-CoV-2 in Korea for 1 year (January 2020 to January 2021). A total of 2,488 SARS-CoV-2 cases were sequenced (including 648 cases from abroad). Initially, the prevalent clades of SARS-CoV-2 were the S and V clades, however, by March 2020, GH clade was the most dominant. Only international travelers were identified as having G or GR clades, and since the first variant 501Y.V1 was identified (from a traveler from the United Kingdom on December 22^nd, 2020), a total of 27 variants of 501Y.V1, 501Y.V2, and 484K.V2 have been classified (as of January 25^th, 2021). The results in this study indicated that quarantining of travelers entering Korea successfully prevented dissemination of the SARS-CoV-2 variants in Korea.

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Replication kinetics and infectivity of SARS-CoV-2 Omicron variant sublineages recovered in the Republic of Korea
Jeong-Min Kim, Dongju Kim, Jee Eun Rhee, Cheon Kwon Yoo, Eun-Jin Kim
Osong Public Health and Research Perspectives.2024; 15(3): 260. CrossRef
Genomic Analysis and Tracking of SARS‐CoV‐2 Variants in Gwangju, South Korea, From 2020 to 2022
Yeong‐Un Lee, Kwangho Lee, Hongsu Lee, Jung Wook Park, Sun‐Ju Cho, Ji‐Su Park, Jeongeun Mun, Sujung Park, Cheong‐mi Lee, Juhye Lee, Jinjong Seo, Yonghwan Kim, Sun‐Hee Kim, Yoon‐Seok Chung
Influenza and Other Respiratory Viruses.2024;[Epub] CrossRef
Dynamics of SARS-CoV-2 variants during the XBB wave in the Republic of Korea
Jin Sun No, Ji Yeong Noh, Chae Young Lee, Il-Hwan Kim, Jeong-Ah Kim, Yu Jeong Ahn, Hyeokjin Lee, Jeong-Min Kim, Nam-Joo Lee, Dong-Wook Lee, Jeong-Hoon Kwon, JeeEun Rhee, Eun-Jin Kim
Virus Research.2024; 350: 199471. CrossRef
Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea
Jeong-Min Kim, Dongju Kim, Nam-Joo Lee, Sang Hee Woo, Jaehee Lee, Hyeokjin Lee, Ae Kyung Park, Jeong-Ah Kim, Chae Young Lee, Il-Hwan Kim, Cheon Kwon Yoo, Eun-Jin Kim
Osong Public Health and Research Perspectives.2023; 14(4): 272. CrossRef
Rapid Emergence of the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 in Korea
Ae Kyung Park, Il-Hwan Kim, Chae Young Lee, Jeong-Ah Kim, Hyeokjin Lee, Heui Man Kim, Nam-Joo Lee, SangHee Woo, Jaehee Lee, JeeEun Rhee, Cheon-Kwon Yoo, Eun-Jin Kim
Annals of Laboratory Medicine.2023; 43(2): 211. CrossRef
A Seroprevalence Study on Residents in a Senior Care Facility with Breakthrough SARS-CoV-2 Omicron Infection
Heui Man Kim, Eun Ju Lee, Sang Won O, Yong Jun Choi, Hyeokjin Lee, Sae Jin Oh, Jeong-Min Kim, Ae Kyung Park, Jeong-Ah Kim, Chae young Lee, Jong Mu Kim, Hanul Park, Young Joon Park, Jeong-Hee Yu, Eun-Young Kim, Hwa-Pyeong Ko, Eun-Jin Kim
Viral Immunology.2023; 36(3): 203. CrossRef
COVID-19 Cases and Deaths among Healthcare Personnel with the Progression of the Pandemic in Korea from March 2020 to February 2022
Yeonju Kim, Sung-Chan Yang, Jinhwa Jang, Shin Young Park, Seong Sun Kim, Chansoo Kim, Donghyok Kwon, Sang-Won Lee
Tropical Medicine and Infectious Disease.2023; 8(6): 308. CrossRef
The COVID-19 pandemic and healthcare utilization in Iran: evidence from an interrupted time series analysis
Monireh Mahmoodpour-Azari, Satar Rezaei, Nasim Badiee, Mohammad Hajizadeh, Ali Mohammadi, Ali Kazemi-Karyani, Shahin Soltani, Mehdi Khezeli
Osong Public Health and Research Perspectives.2023; 14(3): 180. CrossRef
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Alexander M Kramer, Bryan Thornlow, Cheng Ye, Nicola De Maio, Jakob McBroome, Angie S Hinrichs, Robert Lanfear, Yatish Turakhia, Russell Corbett-Detig, Olivier Gascuel
Systematic Biology.2023; 72(5): 1039. CrossRef
Genomic epidemiology of SARS-CoV-2 variants in South Korea between January 2020 and February 2023
Il-Hwan Kim, Jin Sun No, Jeong-Ah Kim, Ae Kyung Park, HyeokJin Lee, Jeong-Min Kim, Nam-Joo Lee, Chi-Kyeong Kim, Chae Young Lee, SangHee Woo, Jaehee Lee, JeeEun Rhee, Eun-Jin Kim
Virology.2023; 587: 109869. CrossRef
Genomic evidence of SARS‐CoV‐2 reinfection in the Republic of Korea
Ae Kyung Park, Jee Eun Rhee, Il‐Hwan Kim, Heui Man Kim, Hyeokjin Lee, Jeong‐Ah Kim, Chae Young Lee, Nam‐Joo Lee, SangHee Woo, Jaehee Lee, Jin Sun No, Gi‐Eun Rhie, Seong Jin Wang, Sang‐Eun Lee, Young Joon Park, Gemma Park, Jung Yeon Kim, Jin Gwack, Cheon‐K
Journal of Medical Virology.2022; 94(4): 1717. CrossRef
SARS-CoV-2 B.1.619 and B.1.620 Lineages, South Korea, 2021
Ae Kyung Park, Il-Hwan Kim, Heui Man Kim, Hyeokjin Lee, Nam-Joo Lee, Jeong-Ah Kim, SangHee Woo, Chae young Lee, Jaehee Lee, Sae Jin Oh, JeeEun Rhee, Cheon-Kwon Yoo, Eun-Jin Kim
Emerging Infectious Diseases.2022; 28(2): 415. CrossRef
Humoral and Cellular Responses to COVID-19 Vaccines in SARS-CoV-2 Infection-Naïve and -Recovered Korean Individuals
Ji-Young Hwang, Yunhwa Kim, Kyung-Min Lee, Eun-Jeong Jang, Chang-Hoon Woo, Chang-Ui Hong, Seok-Tae Choi, Sivilay Xayaheuang, Jong-Geol Jang, June-Hong Ahn, Hosun Park
Vaccines.2022; 10(2): 332. CrossRef
Increase in Viral Load in Patients With SARS-CoV-2 Delta Variant Infection in the Republic of Korea
Jeong-Min Kim, Jee Eun Rhee, Myeongsu Yoo, Heui Man Kim, Nam-Joo Lee, Sang Hee Woo, Hye-Jun Jo, Donghyok Kwon, Sangwon Lee, Cheon Kwon Yoo, Eun-Jin Kim
Frontiers in Microbiology.2022;[Epub] CrossRef
Molecular Dynamics Studies on the Structural Stability Prediction of SARS-CoV-2 Variants Including Multiple Mutants
Kwang-Eun Choi, Jeong-Min Kim, Jee Eun Rhee, Ae Kyung Park, Eun-Jin Kim, Cheon Kwon Yoo, Nam Sook Kang
International Journal of Molecular Sciences.2022; 23(9): 4956. CrossRef
SARS-CoV-2 shedding dynamics and transmission in immunosuppressed patients
Jee-Soo Lee, Ki Wook Yun, Hyeonju Jeong, Boram Kim, Man Jin Kim, Jae Hyeon Park, Ho Seob Shin, Hyeon Sae Oh, Hobin Sung, Myung Gi Song, Sung Im Cho, So Yeon Kim, Chang Kyung Kang, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Myoung-Don Oh, Eun Hwa Choi
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Clinical scoring system to predict viable viral shedding in patients with COVID-19
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Journal of Clinical Virology.2022; 157: 105319. CrossRef
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International Journal of Molecular Sciences.2021; 22(16): 8714. CrossRef
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Taewon Han, Boyeong Ryu, Suyeon Lee, Yugyeong Song, Yoongje Jeong, Ilhwan Kim, Jeongmin Kim, Eunjin Kim, Wonjun Lee, Hyunju Lee, Haekyoung Hwang
One Health.2021; 13: 100328. CrossRef
Genomic epidemiology reveals the reduction of the introduction and spread of SARS-CoV-2 after implementing control strategies in Republic of Korea, 2020
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