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Abbas Bahador 3 Articles
Antibiotic Resistance of Acinetobacter baumannii in Iran: A Systemic Review of the Published Literature
Jale Moradi, Farhad B. Hashemi, Abbas Bahador
Osong Public Health Res Perspect. 2015;6(2):79-86.   Published online April 30, 2015
DOI: https://doi.org/10.1016/j.phrp.2014.12.006
  • 2,148 View
  • 25 Download
  • 43 Citations
AbstractAbstract PDF
Objectives
Acinetobacter baumannii is a bacterium responsible for health care-associated infections, and it frequently develops multiple drug resistance (MDR). The prevalence of antibiotic-resistant A. baumannii in Iran has increased, and this may cause significant clinical problems. Therefore, in order to elucidate the development of antibiotic resistance, we performed a systematic review of the literature published on antibiotic-resistant A. baumannii reported in Iran.
Methods
Thirty-six publications that met the criteria for inclusion were reviewed from an initial 87 papers. Selected papers published between 2008 and September 2014, were categorized on the basis of the sample collecting year been between 2001 and 2013.
Results
Analysis of data revealed that, in general, there was an increase in antimicrobial resistance. During the initial time point of these studies (2001–2007) there was a high rate of resistance to all antibiotics, with the exception of carbapenems, lipopeptides, and aminoglycosides that had a low resistance rate in comparison with the others. Also, the resistance rate was increased in one group of these three antimicrobial groups from 2010 to 2013. In particular, there was an increase in resistance to carbapenems (imipenem and meropenem) from 2010–2011 and 2012–2013, whereas no significant change in the resistance rate of the other two antimicrobial groups (lipopeptides and aminoglycosides) during the study time was observed, although we did observe certain trends in amikacin (aminoglycoside group antibiotic) between 2011–2012 and 2012–2013.
Conclusion
These findings indicate that antimicrobial resistance of A. baumannii in Iran has increased, which may very well affect the antimicrobial resistance of this organism worldwide. Based on these results, novel prevention and treatment strategies against A. baumannii infections are warranted. Furthermore, these data may assist in revising treatment guidelines and regional policies in care units to slow the emergence of antimicrobial resistance.

Citations

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  • Evasion of Antimicrobial Activity in Acinetobacter baumannii by Target Site Modifications: An Effective Resistance Mechanism
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    International Journal of Molecular Sciences.2022; 23(12): 6582.     CrossRef
  • Production of bla oxa-23 type genes carrying by Acinetobacter baumannii isolated from hospitalized patients in Tehran, Iran
    Maryam Rezaei, Jalil vand Yousefi, Naser Harzandi, Monireh Sharifizadeh, Abed Zahedi bialvaei, Mohammad Rahbar
    Reviews in Medical Microbiology.2021; 32(2): 102.     CrossRef
  • Acinetobacter baumannii as a community foodborne pathogen: Peptide mass fingerprinting analysis, genotypic of biofilm formation and phenotypic pattern of antimicrobial resistance
    Ayman Elbehiry, Eman Marzouk, Ihab M. Moussa, Turki M. Dawoud, Ayman S. Mubarak, Dalia Al-Sarar, Roua A. Alsubki, Jwaher H. Alhaji, Mohamed Hamada, Adil Abalkhail, Hassan A. Hemeg, Rasha N. Zahran
    Saudi Journal of Biological Sciences.2021; 28(1): 1158.     CrossRef
  • Mapping Global Prevalence of Acinetobacter baumannii and Recent Vaccine Development to Tackle It
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  • Evaluation of Antibiotic Resistance to Colistin in Nosocomial Infections with Multidrug-Resistant Acinetobacter
    Fariba Keramat, Hamid Reza Ghasemi Basir, Abbas Taher, Abbas Moradi, Ali Saadatmand, Pooria Owji Nejad
    Avicenna Journal of Clinical Medicine.2021; 27(4): 211.     CrossRef
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  • Detection of blaOXA-23 and blaNDM-1 carbapenemase among clinical isolates of A. baumannii in Tabriz, north-west of Iran
    Leila Rahbarnia, Safar Farajnia, Hajar Khaneshi, Hadi Farajnia, Behrooz Naghili, Asghar Tanomand
    Gene Reports.2020; 18: 100555.     CrossRef
  • Prevalence and phenotypic pattern of antibiotic resistance of Acinetobacter baumannii isolated from different types of raw meat samples in Isfahan, Iran
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  • Trend and Characteristics of Acinetobacter baumannii Infections in Patients Attending Universal College of Medical Sciences, Bhairahawa, Western Nepal: A Longitudinal Study of 2018


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  • Evaluating the frequency of carbapenem and aminoglycoside resistance genes among clinical isolates of Acinetobacter baumannii from Ahvaz, south-west Iran
    S.M. Mortazavi, Z. Farshadzadeh, S. Janabadi, M. Musavi, F. Shahi, M. Moradi, S. Khoshnood
    New Microbes and New Infections.2020; 38: 100779.     CrossRef
  • Evaluation of Antibiotic Resistance Pattern of Meropenem and Piperacillin- Tazobactam in Multi Drug Resistant Acinetobacter baumannii Isolates by Flow Cytometry Method
    Nahid Rahimi, Sahar Honarmand Jahromy, Shohreh Zare Karizi
    Iranian Journal of Medical Microbiology.2019; 13(3): 194.     CrossRef
  • Antimicrobial photodynamic therapy against clinical isolates of carbapenem-susceptible and carbapenem-resistant Acinetobacter baumannii
    Mirian Marcolan De Mello, Patrícia Pimentel De Barros, Renata de Cassia Bernardes, Silvio Rubens Alves, Naiara Pires Ramanzini, Lívia Mara Alves Figueiredo-Godoi, Ana Carolina Chipoletti Prado, Antonio Olavo Cardoso Jorge, Juliana Campos Junqueira
    Lasers in Medical Science.2019; 34(9): 1755.     CrossRef
  • Antibacterial Resistance Pattern of Acinetobacter baumannii in Burn Patients in Northeast of Iran
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    Jundishapur Journal of Microbiology.2019;[Epub]     CrossRef
  • Amikacin resistance due to the aphA6 gene in multi-antibiotic resistant Acinetobacter baumannii isolates belonging to global clone 1 from Iran
    Parisa Aris, Mohammad Ali Boroumand, Masoumeh Douraghi
    BMC Microbiology.2019;[Epub]     CrossRef
  • Highly Synergistic Effects of Melittin with Conventional Antibiotics Against Multidrug-Resistant Isolates of Acinetobacter baumannii and Pseudomonas aeruginosa
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    Microbial Drug Resistance.2019; 25(2): 193.     CrossRef
  • Seven-Year Trend of Antimicrobial Resistance of Acinetobacter and Pseudomonas spp. Causing Bloodstream Infections: A Retrospective Study from Shiraz, Southern Iran
    Amir Hossein Babaei, Gholamreza Pouladfar, Bahman Pourabbas, Zahra Jafarpour, Samin Ektesabi, Pejman Abbasi
    Jundishapur Journal of Microbiology.2019;[Epub]     CrossRef
  • Antibacterial Effect Leaf Extract of Avicennia marina on Standard and Clinical Strains of Acinetobacter baumannii
    Mehdi Mahmudpour, Azam Askari, Forough Yousefi
    Iranian South Medical Journal.2019; 22(3): 150.     CrossRef
  • Nucleotide-binding oligomerization domain 1 is dispensable for host immune responses against pulmonary infection of Acinetobacter baumannii in mice
    Min-Jung Kang, Jin-A Choi, Joo-Hee Choi, Ah-Ra Jang, Ji-Yeon Park, Jae-Hun Ahn, Tae-Sung Lee, Dong-Yeon Kim, Jong-Hwan Park
    Laboratory Animal Research.2018; 34(4): 295.     CrossRef
  • Survey of aminoglycoside acetyl transferase genes in multi-drug resistance acinetobacter
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    MOJ Toxicology.2018;[Epub]     CrossRef
  • Cloning and expression of nlpA gene as DNA vaccine candidate against Acinetobacter baumannii
    Rassoul Hashemzehi, Abbas Doosti, Mohammad Kargar, Mojtaba Jaafarinia
    Molecular Biology Reports.2018; 45(4): 395.     CrossRef
  • Association of virulence gene expression with colistin-resistance in Acinetobacter baumannii: analysis of genotype, antimicrobial susceptibility, and biofilm formation
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    Annals of Clinical Microbiology and Antimicrobials.2018;[Epub]     CrossRef
  • Distribution and Genotyping of Aquatic Acinetobacter baumannii Strains Isolated from the Puzi River and Its Tributaries Near Areas of Livestock Farming
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  • Clinical Isolates of Acinetobacter baumannii From Tehran Hospitals: Pulsed-field Gel Electrophoresis Characterization, Clonal Lineages, Antibiotic Susceptibility, and Biofilm-forming Ability
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  • Polyclonal Distribution of blaOXA-23 Gene Among Acinetobacter baumannii Isolated from Intensive Care Unit Patients in Tehran; Pulsed-Field Gel Electrophoresis Analysis
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    Jundishapur Journal of Microbiology.2017;[Epub]     CrossRef
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  • Acinetobacter baumannii strains isolated from patients in intensive care units in Goiânia, Brazil: Molecular and drug susceptibility profiles
    Suellen Rocha Araújo Castilho, Cássia Silva de Miranda Godoy, Adriana Oliveira Guilarde, Juliana Lamaro Cardoso, Maria Cláudia Porfirio André, Ana Paula Junqueira-Kipnis, André Kipnis, Patrick Butaye
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  • Antimicrobial resistance profiles and genetic elements involved in carbapenem resistance in Acinetobacter baumannii isolates from a referral hospital in Southern Iran
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  • Characterization of integrons and associated gene cassettes in Acinetobacter baumannii strains isolated from intensive care unit in Tehran, Iran
    Hossein Goudarzi, Mehdi Azad, Sima Sadat Seyedjavadi, Hadi Azimi, Alireza Salimi Chirani, Vahid Fallah Omrani, Mehdi Goudarzi
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  • Genotypic and Antimicrobial Susceptibility of Carbapenem-resistant Acinetobacter baumannii: Analysis of is Aba Elements and blaOXA-23-like Genes Including a New Variant
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    Frontiers in Microbiology.2015;[Epub]     CrossRef
  • Bacterial Etiology and Antibacterial Susceptibility Patterns of Pediatric Bloodstream Infections: A Two Year Study From Nemazee Hospital, Shiraz, Iran
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  • Wide distribution of carbapenem resistant Acinetobacter baumannii in burns patients in Iran
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Frequencies of CD4+ T Regulatory Cells and their CD25high and FoxP3high Subsets Augment in Peripheral Blood of Patients with Acute and Chronic Brucellosis
Abbas Bahador, Jamshid Hadjati, Niloofar Hassannejad, Hadi Ghazanfari, Mohammadreza Maracy, Sirous Jafari, Maryam Nourizadeh, Amirhooshang Nejadeh
Osong Public Health Res Perspect. 2014;5(3):161-168.   Published online June 30, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.04.008
  • 1,798 View
  • 15 Download
  • 8 Citations
AbstractAbstract PDF
Objectives
Brucellosis remains one of the most common zoonotic diseases worldwide. In humans, brucellosis can be a serious, debilitating, and sometimes chronic disease. Different mechanisms can be postulated as to the basis for the induction of the chronic status of infectious diseases that T regulatory cells are one of the most important related mechanisms. The current study was designed to determine whether percentage of CD4+Treg cells and their CD25high and FoxP3high subpopulations in peripheral blood are changed in human brucellosis samples in comparison to a control group.
Methods
In total, 68 brucellosis patients (acute form: n = 43, chronic form: n = 25) and 36 healthy volunteers entered our study. After isolating of peripheral blood mononuclear cells, heparinized venous blood samples were obtained from both patients and healthy donors, CD4, CD25, and FoxP3 molecules were evaluated by two- and three-color flow cytometric methods.
Results
The results revealed a new finding in relation to Treg cells and human brucellosis. The numbers of CD4+Treg cells and their CD25high and FoxP3high subsets increase significantly in the peripheral blood of acute and chronic forms of brucellosis samples compared with healthy groups, with this increase being greater in the chronic group.
Conclusion
There seems to be a correlation between increase of CD4+Treg cells and their subsets and the disease progress from healthy state to acute and chronic brucellosis.

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    eBioMedicine.2022; 79: 104010.     CrossRef
  • Cell-Mediated Therapies to Facilitate Operational Tolerance in Liver Transplantation
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  • Effects of indoleamine 2, 3‐dioxygenase (IDO) silencing on immunomodulatory function and cancer‐promoting characteristic of adipose‐derived mesenchymal stem cells (ASCs)
    Fahimeh Heidari, Mahboobeh Razmkhah, Vahid Razban, Nasrollah Erfani
    Cell Biology International.2021; 45(12): 2544.     CrossRef
  • Impact of immune checkpoint molecules on FoxP3+ Treg cells and related cytokines in patients with acute and chronic brucellosis
    Hua-Li Sun, Xiu-Fang Du, Yun-Xia Tang, Guo-Qiang Li, Si-Yuan Yang, Ling-Hang Wang, Xing-Wang Li, Cheng-Jie Ma, Rong-Meng Jiang
    BMC Infectious Diseases.2021;[Epub]     CrossRef
  • Meta-Analysis of the Changes of Peripheral Blood T Cell Subsets in Patients with Brucellosis
    Rongjiong Zheng, Songsong Xie, Shaniya Niyazi, Xiaobo Lu, Lihua Sun, Yan Zhou, Yuexin Zhang, Kai Wang
    Journal of Immunology Research.2018; 2018: 1.     CrossRef
  • Assessment of TGF-β and IL10 levels in human brucellosis
    Mousa Mohammadnia-Afrouzi, Soheil Ebrahimpour
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Virulence Factors of Staphylococcus aureus Isolates in an Iranian Referral Children's Hospital
Farah Sabouni, Shima Mahmoudi, Abbas Bahador, Babak Pourakbari, Reihaneh Hosseinpour Sadeghi, Mohammad Taghi Haghi Ashtiani, Bahram Nikmanesh, Setareh Mamishi
Osong Public Health Res Perspect. 2014;5(2):96-100.   Published online April 30, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.03.002
  • 2,547 View
  • 20 Download
  • 29 Citations
AbstractAbstract PDF
Objectives
The clinical importance of Staphylococcus aureus (S. aureus) is attributed to notable virulence factors, surface proteins, toxins, and enzymes as well as the rapid development of drug resistance. The aim of this study was to compare the occurrence of virulence factors produced by S. aureus strains isolated from children in an Iranian referral children's hospital.
Methods
The presence of genes encoding for the enterotoxins A (sea), B (seb), C (sec), D (sed), TSST-1 (tsst), exfoliative toxin A (eta), and exfoliative toxin B (etb) were detected by Multiplex polymerase chain reaction (PCR) using specific primers. In addition, the standardized Kirby-Bauer disc-diffusion method was performed on Mueller-Hinton agar.
Results
In total, 133 S. aureus isolates were obtained from different patients. Of these S. aureus isolates, 64 (48%) were methicillin-resistant S. aureus (MRSA), and all of these tested positive for the mecA gene. Regarding the classical enterotoxin genes, sea gene (40.6%) was the most prevalent followed by seb (19.6%), tsst (12.8%), eta (11.3%), etb (9%), sed (4.5%), and sec (3%). Among methicillin-susceptible S. aureus (MSSA) isolates, seb and tsst were the more prevalent toxins in comparison with MRSA isolates (p < 0.05), while the frequency of sea, sed, eta, and etb genes were higher among MRSA isolates (p > 0.05).
Conclusion
In our study enterotoxin A was produced by 40.6% of the isolates (48% from MRSA and 33% from MSSA isolates) which was higher than in previous reports. According to our results, strict hygiene and preventative measures during food processing are highly recommended.

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    Molecular Biology Reports.2022; 49(4): 3099.     CrossRef
  • Investigation of Virulence Genes of the Predominant Bacteria Associated with Renal Stones and their Correlation with Postoperative Septic Complications
    Asmaa E Ahmed, Hassan Abol-Enein, Amira Awadalla, Heba El degla, Omar A El-Shehaby
    Infection and Drug Resistance.2022; Volume 15: 3643.     CrossRef
  • Virulence genes distributed among Staphylococcus aureus causing wound infections and their correlation to antibiotic resistance
    Asia Helmi Rasmi, Eman Farouk Ahmed, Abdou Mohammed Abdullah Darwish, Gamal Fadl Mahmoud Gad
    BMC Infectious Diseases.2022;[Epub]     CrossRef
  • Genetic Diversity and Virulence Profile of Methicillin and Inducible Clindamycin-Resistant Staphylococcus aureus Isolates in Western Algeria
    Zahoua Mentfakh Laceb, Seydina M. Diene, Rym Lalaoui, Mabrouk Kihal, Fella Hamaidi Chergui, Jean-Marc Rolain, Linda Hadjadj
    Antibiotics.2022; 11(7): 971.     CrossRef
  • Antimicrobial susceptibility and genotyping of microorganisms isolated from sputum culture of children with cystic fibrosis in an Iranian referral children’s hospital
    Setareh Mamishi, Arezu Akhlaghi, Babak Pourakbari, Mohammadreza Modaresi, Mohammad Taghi Haghi Ashtiani, Reihaneh Hosseinpour Sadeghi, Rohola Shirzadi, Zohreh Shalchi, Shima Mahmoudi
    Wiener Medizinische Wochenschrift.2022;[Epub]     CrossRef
  • Phenotypic and genotypic virulence features of staphylococcal strains isolated from difficult-to-treat skin and soft tissue infections
    Mădălina Preda, Mara Mădălina Mihai, Laura Ioana Popa, Lia-Mara Dițu, Alina Maria Holban, Loredana Sabina Cornelia Manolescu, Gabriela-Loredana Popa, Andrei-Alexandru Muntean, Irina Gheorghe, Carmen Mariana Chifiriuc, Mircea-Ioan Popa, Keun Seok Seo
    PLOS ONE.2021; 16(2): e0246478.     CrossRef
  • Distribution of virulence genes and SCCmec types among methicillin-resistant Staphylococcus aureus of clinical and environmental origin: a study from community of Assam, India
    Deepshikha Bhowmik, Shiela Chetri, Bhaskar Jyoti Das, Debadatta Dhar Chanda, Amitabha Bhattacharjee
    BMC Research Notes.2021;[Epub]     CrossRef
  • The anti-biofilm capability of nano-emodin-mediated sonodynamic therapy on multi-species biofilms produced by burn wound bacterial strains
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  • Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis
    Farhad Sarrafzadeh, Seyed Mojtaba Sohrevardi, Hamid Abousaidi, Hossein Mirzaei
    Clinical and Experimental Pediatrics.2021; 64(8): 415.     CrossRef
  • Interactions between staphylococcal enterotoxins A and D and superantigen-like proteins 1 and 5 for predicting methicillin and multidrug resistance profiles among Staphylococcus aureus ocular isolates
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    PLOS ONE.2021; 16(7): e0254519.     CrossRef
  • Four Weeks Exercise in Vary Intensities Reduce More Inguinal Fat Than Perigonadal Fat in Mice
    Ahmad Rukhani Lutfi, Paulus Liben, Lilik Herawati
    Folia Medica Indonesiana.2021; 57(2): 121.     CrossRef
  • Molecular Genotyping of Tsst-1 Gene Staphylococcus Aureus from Clinical Specimen
    Marinda Dwi Puspitarini, Kuntaman Kuntaman, Eddy Bagus Wasito, Wahyu Setyarini
    Folia Medica Indonesiana.2021; 57(2): 129.     CrossRef
  • Prevalence of enterotoxin genes (SEA to SEE) and antibacterial resistant pattern of Staphylococcus aureus isolated from clinical specimens in Assiut city of Egypt
    Ahmed A. Baz, Elsayed K. Bakhiet, Usama Abdul-Raouf, Ahmed Abdelkhalek
    Egyptian Journal of Medical Human Genetics.2021;[Epub]     CrossRef
  • Contemporary systematic review and meta-analysis of exfoliative toxin-producing Staphylococcus aureus strains isolated from patients in Iran
    Mojtaba Memariani, Hamed Memariani, Mohammad Shahidi-Dadras, Zohreh Tehranchinia, Fariba Ghalamkarpour, Hamideh Moravvej
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PHRP : Osong Public Health and Research Perspectives