Skip Navigation
Skip to contents

PHRP : Osong Public Health and Research Perspectives


Author index

Page Path
HOME > Articles and issues > Author index
Mustofa 1 Article
The Prevalence of CYP2B6 Gene Polymorphisms in Malaria-endemic Population of Timor in East Nusa Tenggara Indonesia
Linawati Hananta, Indwiani Astuti, Ahmad Hamim Sadewa, Josephine Alice, Jontari Hutagalung, Mustofa
Osong Public Health Res Perspect. 2018;9(4):192-196.   Published online August 31, 2018
  • 6,043 View
  • 51 Download
  • 9 Crossref
AbstractAbstract PDF

The CYP2B6 is one of the most polymorphic CYP genes in humans that has the potential to modify the pharmacological and toxicological responses to clinically important drugs such as antimalarial artemisinin and its derivatives. The aim of the study was to determine the frequency of CYP2B6 polymorphisms in Timor malaria endemic area, East Nusa Tenggara, Indonesia where Artemisin-based Combination Therapy (ACT) has been used to treat uncomplicated malaria.


A total of 109 healthy subjects were participated in this study. CYP2B6*4, *6 and *9 polymorphisms were analyzed using PCR-RFLP to confirm the SNPs prevalence of 516G>T and 785A>G in exon 4 and 5.


There were 96 subjects included in the analysis. In the exon 4 of CYP2B6 516G>T, the frequency of the T mutation was 37.5% (39/96), and the wildtype 27.1% (26/96). In the exon 5, CYP2B6 785A>G mutant was detected in 29.2% (28/96) of individuals, and the wildtype allele in 35.4% (34/96). The frequency of CYP2B6*9 (516G>T), CYP2B6*4 (785A>G) and CYP2B6*6 (516G>T and 785A>G) were 40.6%, 29.2% and 22.9%, respectively. The prevalence of these CYP2B6 gene polymorphisms in Timorian ethnic were higher than that in Malay, Han Chinese, Indian, and Egyptian populations.


The prevalence of these CYP2B6 516G>T and 785A>G polymorphisms in Timorian ethnic is higher than that in other populations. These polymorphisms may affect the metabolism of artemisinin and its derivatives.


Citations to this article as recorded by  
  • Allelic variants of CYP2B6 gene expression and its implication on the pathogenesis of malaria among a cohort of outpatients in North-Central Nigeria
    Olalere Shittu, Mobolanle Oladipo Oniya, Titus Adeniyi Olusi
    Open Health.2023;[Epub]     CrossRef
  • Leveraging Mann–Whitney U test on large-scale genetic variation data for analysing malaria genetic markers
    Kah Yee Tai, Jasbir Dhaliwal, Vinod Balasubramaniam
    Malaria Journal.2022;[Epub]     CrossRef
  • Frequency of CYP2B6 Alleles in Major Iranian Ethnicities, Affecting Response to Efavirenz
    Parham Mardi, Bahareh Tavakoli-Far, Samira Sheibani Nia, Roshanak Jazayeri, Massoud Houshmand, Nadeem Sheikh
    Genetics Research.2022; 2022: 1.     CrossRef
  • Phenotyping Study of Cyclophosphamide 4-Hydroxylation in Malay Cancer Patients
    Yesi Ihdina Fityatal Hasanah, Yahdiana Harahap, Denni Joko Purwanto
    Drug Design, Development and Therapy.2021; Volume 15: 305.     CrossRef
  • CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations—Implication for Drug Safety, Dosing, and Individualized Therapy
    Immaculate M. Langmia, Katja S. Just, Sabrina Yamoune, Jürgen Brockmöller, Collen Masimirembwa, Julia C. Stingl
    Frontiers in Genetics.2021;[Epub]     CrossRef
  • The correlation between the level of 3-hydroxypropyl mercapturic acid, CYP2B6 polymorphisms, and hematuria occurrences after cyclophosphamide administration and its bioanalytical methods: A systematic review
    Yahdiana Harahap, Farhan Nurahman, Denni Joko Purwanto, Arry Yanuar
    Heliyon.2021; 7(10): e08126.     CrossRef
  • Frequencies of CYP2B6∗4,∗5, and ∗6 Alleles within an Iranian Population (Mazandaran)
    Mohammad Bagher Hashemi-Soteh, Elaheh Hosseini, Shokoufeh Fazelnia, Faramarz Ghasemian-Sorbeni, Sara Madahian, Mohammad Reza Shiran, Hafiz Ishfaq Ahmad
    Genetics Research.2021; 2021: 1.     CrossRef
  • In vitro and in silico Determination of the Interaction of Artemisinin with Human Serum Albumin
    S. Ginosyan, H. Grabski, S. Tiratsuyan
    Molecular Biology.2020; 54(4): 586.     CrossRef
  • A Review of Danshen Combined with Clopidogrel in the Treatment of Coronary Heart Disease
    Zhaojian Zhang, Yu Wang, Wangxiao Tan, Siwei Wang, Jinghua Liu, Xiao Liu, Xiaoying Wang, Xiumei Gao
    Evidence-Based Complementary and Alternative Medic.2019; 2019: 1.     CrossRef

PHRP : Osong Public Health and Research Perspectives