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Original Article
A Study of High-Risk Drinking Patterns Among Generations Based on the 2009 Korea National Health and Nutrition Examination Survey
Yeongseon Honga, Sungsoo Chunb, Mieun Yunc, Lydia Sarponmaa Asantec, Chaeshin Chud
Osong Public Health and Research Perspectives 2014;5(1):46-53.
DOI: https://doi.org/10.1016/j.phrp.2014.01.006
Published online: January 31, 2014

aGraduate School of Health and Welfare, Sahmyook University, Seoul, Korea

bDepartment of Health Management, Sahmyook University, Seoul, Korea

cKorea Institute on Alcohol Problems, Sahmyook University, Seoul, Korea

dDivision of Epidemic Intelligence Service, Korea Centers for Disease Control and Prevention, Osong, Korea

∗Corresponding author. chss97@syu.ac.kr
• Received: November 8, 2013   • Revised: January 20, 2014   • Accepted: January 22, 2014

© 2014 Published by Elsevier B.V. on behalf of Korea Centers for Disease Control and Prevention.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Objectives
    The aim of this study was to identify how the drinking patterns of a generation on the paternal side affect those of the next generations by estimating the number of high-risk drinkers by generation according to the Alcohol Use Disorder Identification Test.
  • Methods
    Data were selected from the 2009 Korea National Health and Nutrition Examination Survey conducted by the Korea Centers for Disease Control and Prevention and were analyzed using SPSS 18.0.
  • Results
    Later generations started drinking earlier (62.4%, 71.8% and 91.1%, respectively). The majority of the second generation consumed more than 2–4 drinks a month (83.7%), but only a small proportion experienced difficulty in everyday life (9.6%), felt repentance (9.6%), or experienced memory loss (17.9%) after drinking. Unmarried third-generation adults with high-risk-drinking fathers reported more frequent alcohol consumption [odds ratio (OR) 1.441), greater amounts on one occasion (>7 cups for men, OR 1.661; > 5 cups for women, OR 2.078), temperance failure (OR 2.377), and repentance after drinking (OR 1.577). Unmarried third-generation adults with high-risk-drinking grandfathers consumed greater amounts of alcohol on one occasion (OR 3.642), and unmarried third-generation women more frequently consumed large amounts of alcohol (>5 cups, OR 4.091). Unmarried third-generation adults with high-risk-drinking fathers were more likely to exhibit high-risk drinking patterns (OR 1.608). Second-generation individuals from a high-risk-drinking first generation were more likely to engage in high-risk drinking (OR 3.705).
  • Conclusion
    High-risk drinking by a generation significantly affects the high-risk drinking patterns of subsequent generations.
The 2009 Korea National Health and Nutrition Examination Survey (KNHNES) conducted by the Korea Centers for Disease Control and Prevention (KCDC) revealed rates of monthly alcohol consumption and high-risk (HR) drinking of 59.4% and 17.1%, respectively [1]. This rate of HR drinking is very high compared to the rates in Japan (12%), Italy (11.2%), Canada (9.5%), the USA (8.2%), Germany (7.9%), Australia (6.3%), France (5.3%), and Sweden (1.5%) [2]. KCDC conducted web-based research into the health-related behaviors of adolescents in 2011 and found that currently drinking students were HR drinkers or consumed HR amounts of alcohol per month (one bottle for men, >5 cups of soju, distilled ethanol) [3].
Korean society has taken a liberal approach to alcohol consumption by young adults, including adolescents, and to drinking patterns and drinking disorders [4,5]. It has been acknowledged that drinking patterns are hard to change, so Korean society encourages onset of drinking under the guidance of fathers or elders [6]. Therefore, the drinking patterns of fathers are related to the onset, amount, and patterns of drinking by Korean adolescents [7]. Studies on family drinking history have shown that parental drinking problems are transmitted to their children [8,9]. Some 30% of study participants were classified as children of alcoholics (COAs) in several studies on problematic children [10–12]. Adult children of alcoholics (ACOAs) are COAs who are older than 18 years and significantly involved in problematic drinking, especially in terms of amount and frequency [10,13]. From a familial perspective, the status of a drinker in a family influences the relationships in the family [14].
Many studies have investigated genetic factors in problematic drink and alcohol addiction [15–17]. A study on adult twins in Australia revealed that two-thirds of the alcoholism risk was determined by genetic effects and one-third by environmental factors [16]. Alcoholics often start with experimental drinking during adolescence, so there have been many studies on factors affecting the onset of drinking. A study of German adolescent twins and their parents showed that their drinking behaviors were more influenced by genetic and social factors or peer pressure than by parental drinking, and genetic factors were stronger for women aged 17–25 years than for men [15]. If the two factors coexisted, the children were at greater risk of alcohol dependence according to interaction between the two factors [17]. Transmission over generations was affected by genetic and psychological factors in children and siblings [18–20].
Therefore, familial factors or the drinking patterns of prior generations are strong candidates for explaining problematic drinking by subsequent generations. A few studies on problematic drinking by college students investigated family history, parental attitudes to children's drinking, and parental drinking behaviors and frequency in Korea [21–24]. However, few study have examined factors that affect the influence of a prior generation on subsequent generations [25].
The aim of this study was to investigate generation effects on drinking patterns among three generations: the first generation, the second generation, and the unmarried third generation. The study data were sampled from 2009 KNHNES raw data, which were collected in 2009 from all of the Korean population aged ≥19 years by KCDC.
2.1 Study subjects and data
The 2009 KNHNES population comprised adults aged ≥19 years residing in Korea. All households in sampling locations identified by local administrative units were systematically selected and enlisted. All adults in the sampled households were interviewed, which yielded a total of 227,700 interviewees. We selected 1258 households for which three generations (grandparents, parents, and unmarried adult children) resided in one household. Among the first- and second-generation individuals, women were excluded because they traditionally have very low rates of drinking in general and of HR drinking. Data were analyzed for 242 first-generation, 1232 second-generation, and 1733 third-generation (833 men, 850 women) individuals.
2.2 Study tool
Drinking-related questionnaires in the 2009 KNHNES were selected and utilized for this study. We selected as variables age, sex, and questions on current drinking status and the Alcohol Use Disorder Identification Test (AUDIT). Questions on current drinking status consisted of lifetime drinking history, onset age, current drinking, frequency, amount on one occasion, and HR drinking. The AUDIT scale of Babor et al was selected. Abstinence failures, daily life disorder, hangover, repentance, memory loss, and injury after drinking, and abstinence recommended by a doctor were included in the AUDIT questions. A score of <8 was considered non-high-risk (NHR) drinking, and a score of ≥8 was defined as alcohol disorder. For the Korean standard of Lee et al, we classified 12 as the cutoff point for further analysis. The World Health Organization defines a standard drink as 12 g (±20%) of pure ethanol, regardless of alcohol beverage type [26]. HR drinking is classified as five or more weekly standard drinks and the limit for women is 50–80% of that for men [27]. In this study we defined HR drinking as seven cups or five cans of beer on one occasion per month for men, and five cups or three cans of beer for women, considering the size of a cup and the ethanol content in Korea in previous studies [28]. For logistic regression analysis, drinking was defined as one cup or more per year. The onset age for drinking was classified as ≤20 years or ≥21 years and the amount on one occasion as <five cups or ≥five cups. Answers to questions on injury after drinking and abstinence recommended by a doctor were yes or no. For comparison among generations, 0 was assigned to a score of <8 and 1 for ≥8 in the AUDIT8 test, and 0 for a score of <12 and 1 for ≥12 in the AUDIT12 test.
2.3 Data analysis
We used SPSS 18.0 (SPSS Inc., Chicago, IL, USA) for statistical analysis. The χ2 test for frequency and proportion was performed to compare sociodemographic characteristics for different drinking patterns. The drinking patterns of the first and second generations were compared with those of the unmarried third generation. Simple logistic regression was conducted with drinking frequency, amount on one occasion, HR drinking, and abstinence failures as independent variables and the drinking patterns of prior generations as the dependent variable. To measure the impact of the first generation on the second generation, HR drinkers in the first generation were assigned a value of 1 and NHR drinkers a value of 0; the same assignment was applied for the second generation. To measure the impact of the second generation on the third generation, the same values were assigned to HR and NHR drinkers for each generation.
3.1 Demographic characteristics by generation
A total of 3207 individuals were selected: 242 men in the first generation, 1232 men in the second generations, and 1733 persons in the third generation. The average age was 79.9, 53.4, and 24.4 years for the first, second, and third generations, respectively. The third generation consisted of 883 men (51%) and 850 women (49%).
3.2 Drinking habits by generation
Table 1 shows the drinking patterns by generation. The lifetime drinking rate was 76.9%, 88.3%, and 88.0% for the first, second, and third generations, respectively. Most of the unmarried third generation began drinking at age ≤20 years (91.2% for men, 91.0% for women). The recent generation started drinking earlier than the previous generation. The current rate of drinking was 62.4%, 91.0%, 94.5%, and 92.8% for the first and second generations and third-generation men and women, respectively. The corresponding results for those consuming two or more drinks a month among current drinkers was 64.7%, 83.7%, 68.0%, and 34.5%, so the second generation and third-generation men drank the most. HR drinking was reported for 25.0% of the first generation, 64.1% of the second, and 54.3% of men and 29.7% of women in the third generation, so the second generation had the highest rate. More than one abstinence failures (15.7%), daily life disorder after drinking (9.6%), repentance after drinking (17.9%), and memory loss (10.2%) were highest for the second generation. Abstinence recommended by a doctor was highest for the second generation (33.2%), followed by the first generation (24.9%) and unmarried men in the third generation (12.6%).
3.3 Comparison of drinking patterns among generations
3.3.1

3.3.1 Comparison of the second and third generations

Drinking patterns for the third generation according to those of the second generation are shown in Table 2. A significantly higher proportion of third-generation individuals with a HR-drinking father drank more frequently, drank a greater amount on one occasion, and engaged in HR drinking. The proportion of the third generation who drank twice or more a month was 42.5% and 51.6% for those with NHR and HR fathers, respectively (p < 0.001). Consumption of ≥ five cups on one occasion by the third generation significantly differed by father's HR drinking status (38.6% for NHR vs 47.9% for HR, p < 0.001). The same was true for HR drinking proportions among men (55.6%) and women (30.0%) of the third generation (p < 0.001), abstinence failures (2.5% for NHR vs 6.5% for HR, p < 0.001), and repentance after drinking (6.0% for NHR vs 9.1% for HR, p < 0.030). However, there were no significant differences for daily life disorder after drinking, hangover, memory loss, and injury after drinking, abstinence recommended by a doctor, and AUDIT8 and AUDIT12 scores.
3.3.2

3.3.2 Comparison of the first and third generations

The drinking patterns of the third generation by that of the first generation were similar. The proportion of third-generation individuals with HR-drinking grandfathers was higher for frequency of consumption, amount on one occasion, and HR drinking (Table 3). There were significant differences in consumption of ≥ five cups on one occasion (33.1% for NHR vs 64.3% for HR first generation, p < 0.002). Consumption of ≥ five cups on one occasion also significantly differed among third-generation women (15.5% for NHR vs 42.9% for HR first generation, p < 0.019). However, there were no significant differences in AUDIT8 and AUDIT12.
3.4 Relationship between drinking patterns for prior generations and the third generation
Table 4 shows the relation between the drinking patterns of prior generations and those of the third generation. The drinking patterns of the third generation were significant only for the amount on one occasion and HR drinking by women. Third-generation individuals with HR-drinking grandfathers were 3.64 times more likely to drink ≥ five cups on one occasion (p < 0.003) and third-generation women were 4.09 times more likely to engage in HR drinking (p < 0.026). Third-generation individuals with a HR-drinking father were 1.44 times more likely to consume two or more drinks per month (p < 0.001) and 1.46 times more likely to consume ≥ five cups on one occasion (p < 0.001). Third-generation men and women were 1.66 times and 2.08 times more likely, respectively, to engage in HR drinking (both p < 0.001). Abstinence failures and repentance after drinking were 2.38 times (p < 0.002) and 1.58 times more likely, respectively, in third-generation individuals with HR-drinking fathers (p < 0.032). However, there were no significant differences in AUDIT8 and AUDIT12 scores.
3.5 Impact of previous generations on HR drinking by the next generation
HR drinking by the second generation was associated with HR drinking by the first generation. Likewise, HR drinking by the third generation was related to HR drinking by the second generation. However, there was no relation between HR drinking by the first and third generations (Table 5). For first-generation HR drinkers, their offspring were 3.71 times more likely to be HR drinkers (p < 0.006). For second-generation HR drinkers, their offspring were 1.61 times more likely to be HR drinkers (p < 0.002). Although the probability of being a third-generation HR drinker was 1.67 times greater for those with a HR-drinking grandfather, the difference was not statistically significant. Therefore, a prior generation had a greater impact on HR drinking by its immediate offspring.
HR drinking by the second generation was serious in this study. The rate of HR drinking in KNHNES was also higher for this cohort, at 29.9% for those in their 40s and 30.0% for those in their 50s [1], in accordance with our results. However, we defined HR drinking on a monthly basis, so that the rate of HR drinking was higher than that in the KNHNES results. The rate of HR drinking in Korea is notable, because young adults (18–29 years) in the USA constitute only a quarter of the adult population but account for nearly 50% of the alcohol consumption [29]. In Korea, men in their 40s and 50s are socially active, so the number of injuries caused by drinking was highest among men in their 40s [4]. Drinking by the elderly damages their health because of their low metabolism and interactions with medicines for non-communicable diseases, so the current rate of HR drinking was considered to be relatively low in this study.
HR drinking by the second generation led to higher probability of consumption of more drinks, greater drinking frequency, consumption of greater amounts on one occasion, and HR drinking (Table 5). The probability of HR drinking by third-generation woman was 2.08 times higher (p<0.001). This result is in agreement with previous studies on children who have parents with problematic drinking [13,30].
The drinking patterns of the first generation influenced the third generation, but the magnitude of the impact on the third generation was less than that on the second generation (Tables 4 and 5). HR drinking by the second generation influenced that of the third generation (p < 0.002), but the influence of the first generation on the third generation was relatively lower (Table 5). Interestingly the impact of the first generation on the second generation was lower than the impact of the second generation on the third generation (Table 5). This suggests that the generation effect might be weakened. This is useful in understanding the association between genetic and environmental factors [31].
An interesting result is the lack of significant differences in alcoholic disorder among the generations according to both AUDIT8 and AUDIT12, despite differences in drinking patterns (Tables 2, 3, and 4). In Koreans, drinking has been characterized as excessive and social, but not alcoholism [4], so our results are in agreement with a previous study on alcoholic disorder. Thus, drinking problems exhibited by Koreans are not related to genetics but to familial environment. If parents take a permissive attitude to the children, the onset age and rate of drinking among adolescents were higher in previous studies [32,33]. This is why the second generation had a greater impact on the third generation than the first generation did in this study (Tables 4 and 5). A liberal drinking attitude has been passed down through the generations in family units in Korean society [4]. Drinking problems exhibited by Koreans are not entirely dominated by environmental factors, but they could be a predominant factor. Alcohol-related problems in Korea have become serious in terms of their number, variety, and magnitude [34]. It is necessary to develop a program to block the generation effect in the liberal and permissive drinking environment in Korean society.
KNHNES was a cross-sectional survey, so we did not examine drinking causes and prognosis in this study. Environmental and genetic factors were also not included, although they have been discussed in previous studies. In addition, we did not include women in the first and second generations.
We suggest that education of adolescents, including college students, is necessary because the frequency of drinking was high in those with an onset age of ≤20 years. Abstinence education programs should also be run for middle-aged men. Education programs for family units are necessary because high-risk drinking by a prior generation leads to similar behavior in the next generation.
All contributing authors declare no conflicts of interest.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Table 1
Drinking patterns by generation
Pattern First generation
Second generation
Unmarried third generation
(n = 242) (n = 1231) Men (n = 883) Women (n = 850)
Lifetime drinking history Yes 186 (76.9) 1,087 (88.3) 777 (88.0) 635 (74.7)
No 56 (23.1) 144 (11.7) 106 (12.0) 215 (25.3)
Onset agea ≤20 yr 116 (62.4) 781 (71.8) 709 (91.2) 578 (91.0)
≥21 yr 70 (37.6) 306 (28.2) 68 ( 8.8) 57 ( 9.0)
Current drinkinga Yes 116 (62.4) 989 (91.0) 734 (94.5) 589 (92.8)
No 70 (37.6) 98 (9.0) 43 (5.5) 46 (7.2)
Frequencyb <2 a month 41 (35.3) 161 (16.3) 235 (32.0) 345 (58.6)
≥2 a month 75 (64.7) 828 (83.7) 499 (68.0) 244 (41.4)
Amount on one occasionb <5 cups 84 (72.4) 347 (35.1) 254 (34.6) 386 (65.5)
≥5 cups 32 (27.6) 642 (64.9) 480 (65.4) 203 (34.5)
High-risk drinkingb <1 a month 87 (75.0) 355 (35.9) 335 (45.7) 414 (70.3)
≥1 a month 29 (25.0) 634 (64.1) 398 (54.3) 175 (29.7)
Abstinence failuresb <1 a month 109 (94.0) 834 (84.3) 684 (93.3) 570 (96.8)
≥1 a month 7 ( 6.0) 155 (15.7) 49 (6.7) 19 (3.2)
Daily life disorder after drinkingb <1 a month 113 (97.4) 894 (90.4) 693 (94.4) 573 (97.3)
≥1 a month 3 (2.6) 95 ( 9.6) 41 ( 5.6) 16 ( 2.7)
Hangover after drinkingb <1 a month 112 (94.4) 960 (97.1) 720 (98.1) 586 (99.5)
≥1 a month 4 ( 6.0) 29 ( 2.9) 14 ( 1.9) 3 ( .5)
Repentance after drinkingb <1 a month 109 (94.8) 811 (82.1) 654 (89.1) 553 (93.9)
≥1 a month 7 ( 5.2) 117 (17.9) 80 (10.9) 36 ( 6.1)
Memory loss after drinkingb <1 a month 110 (94.8) 888 (89.8) 705 (96.0) 574 (97.5)
≥1 a month 6 (5.2) 101 (10.2) 29 (4.0) 15 (2.5)
Injury after drinkinga No 173 (93.5) 1034 (95.3) 754 (97.2) 620 (97.6)
Yes 12 ( 6.5) 51 ( 4.7) 22 ( 2.8) 15 ( 2.4)
Abstinence recommended by doctora No 139 (75.1) 725 (66.8) 678 (87.4) 603 (95.0)
Yes 46 (24.9) 360 (33.2) 98 (12.6) 32 ( 5.0)

Data are presented as n (%).

a Among those with a lifetime history of drinking.

b Among those who currently drink.

Table 2
Drinking patterns for the third generation according to drinking risk for the second generation
Pattern Second generation
χ2 p
NHRD (n = 738) HRD (n = 583)
Frequency ≤1 a month 424 (57.5) 282 (48.4) 10.797 0.001
≥2 a month 314 (42.5) 301 (51.6)
Amount on one occasion ≤4 cups 453 (61.4) 304 (52.1) 11.361 0.001
≥5 cups 285 (38.6) 279 (47.9)
Frequency of ≥ 7 cups (men) ≤1 a month 210 (57.1) 136 (44.4) 10.652 0.001
≥2 a month 158 (42.9) 170 (55.6)
Frequency of ≥ 5 cups (women) ≤1 a month 306 (82.9) 194 (70.0) 15.030 0.000
≥2 a month 63 (17.1) 83 (30.0)
Fail to abstinence ≤1 a month 716 (97.2) 545 (93.5) 10.260 0.001
≥2 a month 21 (2.8) 38 (6.5)
Daily life disorder after drinking ≤1 a month 718 (97.3) 556 (95.4) 3.503 0.061
≥2 a month 20 (2.7) 27 (4.6)
Hangover with a drink ≤1 a month 732 (99.2) 575 (98.6) 0.971 0.324
≥2 a month 6 (0.8) 8 (1.4)
Repentance after drinking ≤1 a month 694 (94.0) 530 (90.9) 4.686 0.030
≥2 a month 44 (6.0) 53 (9.1)
Memory loss after drinking ≤1 a month 724 (98.1) 563 (96.6) 3.055 0.081
≥2 a month 14 (1.9) 20 (3.4)
Injury after drinking No 720 (97.6) 569 (97.8) 0.060 0.807
Yes 18 (2.4) 13 (2.2)
Abstinence recommended by doctor No 675 (91.5) 534 (91.8) 0.035 0.851
yes 63 (8.5) 48 (8.2)
AUDIT(8-point scale) Non-problematic (<8) 627 (85.2) 459 (84.9) 0.021 0.886
Problematic (≥8) 109 (14.8) 88 (15.1)
AUDIT(12-point scale) Non-problematic (<12) 674 (91.6) 528 (90.6) 0.411 0.522
Problematic (≥12) 62 (8.4) 55 (9.4)

Data are presented as n (%).

HRD = high-risk drinking; NHRD = non-high-risk drinking.

Table 3
Drinking patterns for the third generation according to drinking risk for the first generation
Pattern First generation
χ2 p
NHRD (n = 130) HRD (n = 28)
Frequency ≤1 a month 78 (60.0) 13 (46.4) 1.737 0.187
≥2 a month 52 (40.0) 15 (53.6)
Amount on one occasion ≤4 cups 37 (66.9) 10 (35.7) 9.467 0.002
≥5 cups 43 (33.1) 18 (64.3)
Frequency of ≥ 7 cups (men) ≤1 a month 34 (57.6) 7 (50.0) 0.267 0.605
≥2 a month 25 (42.4) 7 (50.0)
Frequency of ≥5 cups (women) ≤1 a month 60 (84.5) 8 (57.1) 5.473 0.019
≥2 a month 11 (15.5) 6 (42.9)
AUDIT(8-point scale) Non-problematic (<8) 105 (81.4) 24 (85.7) 0.293 0.588
Problematic (≥8) 24 (18.6) 4 (14.3)
AUDIT(12-point scale) Non-problematic (<12) 117 (90.7) 26 (92.9) 0.132 0.716
Problematic (≥12) 12 (9.3) 2 (7.1)

Data are presented as n (%).

HRD = high-risk drinking; NHRD = non-high-risk drinking.

Table 4
Drinking patterns for the third generation according to drinking risk for previous generations
Pattern First generation (n = 242)
Second generation (n = 1232)
OR (95% CI) p OR (95% CI) p
Frequency ≤1 a month 1 0.191 1 0.001
≥2 a month 1.73 (0.76–3.94) 1.44 (1.16–1.80)
Amount on one occasion ≤4 cups 1 0.003 1 0.001
≥5 cups 3.64 (1.55–8.57) 1.46 (1.17–1.82)
Frequency of ≥7 cups (men) ≤1 a month 1 0.606 1 0.001
≥2 a month 1.36 (0.42–4.37) 1.66 (1.22–2.26)
Frequency ≥5 cups (women) ≤1 a month 1 0.026 1 0.000
≥2 a month 4.09 (1.186–14.11) 2.08 (1.43–3.02)
Abstinence failures ≤1 a month 1 0.002
≥2 a month 2.38 (1.38–4.10)
Daily life disorder after drinking ≤1 a month 1 0.064
≥2 a month 1.74 (0.97–3.14)
Hangover with a drink ≤1 a month 1 0.330
≥2 a month 1.70 (0.59–4.92)
Repentance after drinking ≤1 a month 1 0.032
≥2 a month 1.58 (1.04–2.39)
Memory loss after drinking ≤1 a month 1 0.085
≥2 a month 1.84 (0.92–3.67)
Injury after drinking No 1 0.807
Yes 0.91 (0.44–1.88)
Abstinence recommended by doctor No 1 0.851
Yes 0.96 (0.65–1.43)
AUDIT (8-point scale) Non-problematic (<8) 1 0.590 1 0.886
Problematic (≥8) 0.73 (0.23–2.30) 1.02 (0.75–1.39)
AUDIT(12-point scale) Non-problematic (<12) 1 0.717 1 0.522
Problematic (≥12) 0.75 (0.16–3.56) 1.13 (0.77–1.66)

Odds ratios calculated using the non-high-risk group in the relevant generation as a reference.

CI = confidence interval; OR = odds ratio.

Table 5
Impact of prior generations on subsequent generations
OR (95% CI) p
Second generation
Non-high-risk first generation 1 0.006
High-risk first generation 3.71 (1.47–9.37)
Third generation
Non-high-risk first generation 1 0.400
High-risk first generation 1.67 (0.53–5.31)
Non-high-risk second generation 1 0.002
High-risk second generation 1.61 (1.18–2.19)

CI = confidence interval; OR = odds ratio.

Figure & Data

References

    Citations

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